Zerbini Valentina, Piva Tommaso, Raisi Andrea, Menegatti Erica, Mazzoni Gianni, Grazzi Giovanni, Mandini Simona
Center for Exercise Science and Sport, Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.
Department of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, Italy.
J Funct Morphol Kinesiol. 2025 May 17;10(2):181. doi: 10.3390/jfmk10020181.
: This study aimed to investigate associations between walking speed (WS) and mortality among cardiac patients with type 2 diabetes. : Of the 3328 patients included in the ITER registry between 1998 and 2023, 490 patients diagnosed with type 2 diabetes (mean age 67 ± 9 years) were categorized into tertiles based on WS measured at baseline. Walking speed was measured using the 1 km treadmill walking test (1km-TWT). Cox proportional hazard models were used to examine associations between WS and all-cause and cardiovascular disease mortality, adjusting for demographic and clinical confounders. : The results showed a significative inverse association between WS and mortality. A total of 205 patients died over a median follow-up of 11 years. Patients with a higher baseline WS reported a lower mortality risk compared to slow walkers. A similar magnitude was confirmed by the sensitivity analysis excluding people who died in the first three years. : The 1km-TWT is an effective predictor of mortality among cardiac patients with type 2 diabetes and a valuable educational tool for exercise-based interventions in secondary prevention. These findings highlight the efficacy of exercise-based programs to improve physical function and reduce mortality risk, underscoring the importance of promoting exercise as part of long-term cardiovascular disease management.
本研究旨在调查2型糖尿病心脏病患者的步行速度（WS）与死亡率之间的关联。在1998年至2023年纳入ITER注册研究的3328例患者中，490例被诊断为2型糖尿病的患者（平均年龄67±9岁）根据基线时测量的WS分为三分位数。步行速度采用1公里跑步机步行试验（1km-TWT）进行测量。使用Cox比例风险模型来检验WS与全因死亡率和心血管疾病死亡率之间的关联，并对人口统计学和临床混杂因素进行了调整。结果显示WS与死亡率之间存在显著的负相关。在中位随访11年期间，共有205例患者死亡。与步行速度慢的患者相比，基线WS较高的患者报告的死亡风险较低。通过排除前三年死亡的患者进行敏感性分析，证实了类似的幅度。1km-TWT是2型糖尿病心脏病患者死亡率的有效预测指标，也是二级预防中基于运动的干预措施的有价值的教育工具。这些发现突出了基于运动的项目在改善身体功能和降低死亡风险方面的功效，强调了将运动作为长期心血管疾病管理一部分的重要性。
