Cupellaro Simone, Colonnello Valentina, Sabatello Ugo, Ubertini Chiara, Sogos Carla
Department of Human Neuroscience, Sapienza University, Via dei Sabelli 108, 00185 Rome, Italy.
Department of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Pediatr Rep. 2025 May 8;17(3):55. doi: 10.3390/pediatric17030055.
: This study of endophenotypes represents a new research approach to overcome the limits of a syndromic model to psychiatric diseases. The Affective Neuroscience Personality Scales (ANPS, 31) is a self-report questionnaire used to facilitate the transition from the syndromic to the endophenotypic model through the assessment of basic emotional systems described by Panksepp (1): SEEKING, PLAY, CARE, FEAR, RAGE, PANIC, and LUST. The ANPS was used with adults, but it may be important to investigate the expression of basic emotional systems in childhood clinical disorders. : The present study compares the ANPS scores of a group of children ( = 71) with internalizing disorders (diagnoses of depression and anxiety) with those of a normative group ( = 208) (8-13 years). : We found that the group with internalizing disorders showed significantly lower scores for SEEKING and PLAY and significantly higher scores for ANGER and SADNESS than the control group. Furthermore, depressed children reported significantly lower scores in the SEEKING, PLAY, CARE scales and higher scores in the ANGER and SADNESS scales than healthy children. The children with anxiety disorder had significantly lower scores in the SEEKING and PLAY scales and higher scores in the FEAR and SADNESS scales than control children. No significant effect was found in reference to the age of the children. The results indicate that the ANPS might be a useful instrument to assess the expression of emotional endophenotypes in childhood.
这项关于内表型的研究代表了一种新的研究方法，以克服综合征模型在精神疾病研究中的局限性。情感神经科学人格量表（ANPS，31）是一种自我报告问卷，用于通过评估潘克塞普（1）所描述的基本情绪系统，促进从综合征模型向内表型模型的转变：寻求、玩耍、关爱、恐惧、愤怒、恐慌和欲望。ANPS已应用于成年人，但研究儿童临床疾病中基本情绪系统的表达可能也很重要。本研究比较了一组患有内化障碍（抑郁症和焦虑症诊断）的儿童（n = 71）与一个正常组（n = 208）（8至13岁）的ANPS分数。我们发现，患有内化障碍的组在寻求和玩耍方面的得分显著低于对照组，而在愤怒和悲伤方面的得分显著高于对照组。此外，与健康儿童相比，抑郁儿童在寻求、玩耍、关爱量表上的得分显著更低，而在愤怒和悲伤量表上的得分更高。患有焦虑症的儿童在寻求和玩耍量表上的得分显著低于对照组儿童，而在恐惧和悲伤量表上的得分更高。未发现儿童年龄有显著影响。结果表明，ANPS可能是评估儿童情绪内表型表达的一种有用工具。
