Long term alcohol consumption induces microtubular changes in the adult rat cerebellar cortex.

The effects of prolonged alcohol consumption on the microtubules of Purkinje cell dendrites and granule cell axons were studied in adult rats fed alcohol for 1, 3, 6, 12 and 18 months and compared with respective age-matched controls. A significant consequential decrease in the number of dendritic microtubules in alcohol-fed rats was found when compared with the respective controls. Conversely, an increase in the number of these organelles was found in both ascending and parallel portion of the axons in the experimental animals. The possibility of a relationship between microtubular changes and previously reported cerebellar cortex alcohol-induced structural alterations is advanced.