Van der Vijgh W J, Verbeek P C, Klein I, Pinedo H M
Cancer Lett. 1985 Aug;28(1):103-9. doi: 10.1016/0304-3835(85)90098-9.
Three groups of 6 rats were treated with cisplatin (3 mg/kg, bolus and 3-h infusion) and spiroplatin (3 mg/kg, bolus) by infusion in the right external jugular vein. The mean amounts of platinum +/- c.v. excreted in the bile during the first 6 h after the start of administration were 0.32 +/- 0.19% and 0.39 +/- 0.29% of the dose after bolus injection and 3-h infusion of cisplatin, respectively, and 3.77 +/- 3.32% of the dose after spiroplatin. The values were not significantly different between the 2 cisplatin administration modes (P greater than 0.05), but were between the spiroplatin and cisplatin bolus groups (Wilcoxon two-sided rank test, P less than 0.01). These data are related to pharmacokinetic parameters in man.
将三组每组6只大鼠通过右颈外静脉输注给予顺铂（3mg/kg，推注及3小时输注）和螺铂（3mg/kg，推注）。给药开始后最初6小时内胆汁中铂的平均排泄量（±变异系数），顺铂推注及3小时输注后分别为剂量的0.32±0.19%和0.39±0.29%，螺铂给药后为剂量的3.77±3.32%。两种顺铂给药方式之间的值无显著差异（P＞0.05），但螺铂组与顺铂推注组之间有差异（Wilcoxon双侧秩和检验，P＜0.01）。这些数据与人体药代动力学参数相关。
