Li Zhao, Huang Jiaojiao, Chen Xiaoyu, Yao Lei, Zhao Xianlong, Liu Chang, Zhang Hao, Song Zhenhua, Wang Jin-Hui
Department of Pharmacology, Qingdao University, School of Pharmacy, Qingdao, Shandong, 266021, China.
Department of Biology, College of Life Sciences, Qingdao Agricultural University, Qingdao, 266109, China.
Soc Cogn Affect Neurosci. 2025 Jan 18;20(1). doi: 10.1093/scan/nsaf054.
Social interaction with confidantes and living in groups are thought of as effective approaches to relieve affective disorders, especially major depression. The molecular mechanisms underlying this effectiveness remain largely unknown. Here, periodic interaction with confidante was used to study the effect of social support on depression-like behaviours induced by chronic unpredicted mild stress (CUMS), and high-throughput sequencing was used to analyse the miRNA and mRNA profiles in amygdala harvested from susceptible mice and resilience mice. The results showed that periodic interaction with confidante ameliorated CUMS-induced depression-like behaviours, and 194 differentially expressed genes (DEGs) were found to be associated with depression-like behaviours, 29 DEGs associated with resilience behaviours, and 152 DEGs associated with periodic meeting confidante. In addition, 98 differentially expressed microRNAs are associated with the relief of depression by confidantes. The microRNA-mRNA network associated with confidante-relieved depression has been established in the amygdala, based on our studies in microRNA and mRNA profiles. Taken together, our studies have revealed the potential new approach to improve depression-like behaviours induced by chronic stress, as well as many potential drug targets to prevent and treat major depression.
与知己进行社交互动以及群居被认为是缓解情感障碍，尤其是重度抑郁症的有效方法。这种有效性背后的分子机制在很大程度上仍然未知。在这里，通过与知己定期互动来研究社会支持对慢性不可预测轻度应激（CUMS）诱导的抑郁样行为的影响，并使用高通量测序分析从易感小鼠和抗逆小鼠收集的杏仁核中的miRNA和mRNA谱。结果表明，与知己定期互动可改善CUMS诱导的抑郁样行为，发现194个差异表达基因（DEG）与抑郁样行为相关，29个DEG与抗逆行为相关，152个DEG与定期与知己会面相关。此外，98个差异表达的microRNA与知己缓解抑郁有关。基于我们对microRNA和mRNA谱的研究，已在杏仁核中建立了与知己缓解抑郁相关的microRNA-mRNA网络。综上所述，我们的研究揭示了改善慢性应激诱导的抑郁样行为的潜在新方法，以及许多预防和治疗重度抑郁症的潜在药物靶点。
