[甲氧苄啶体外处理成纤维细胞中核酸与蛋白质合成的细胞化学分析]
[Cytochemical analysis of nucleic acid and protein synthesis in fibroblasts treated in vitro by trimethoprim].
作者信息
Bassleer R, De Paermentier F
出版信息
C R Acad Hebd Seances Acad Sci D. 1977 Feb 21;284(8):651-3.
PMID:404083
Abstract
Chick embryo fibroblasts cultivated in vitro are treated with trimethoprim. The mitotic activity is strongly depressed. DNA and overall RNA and protein syntheses are inhibited. However, these effects are observed only when the concentration of the drug in the culture medium is relatively high.
摘要
体外培养的鸡胚成纤维细胞用甲氧苄啶处理。有丝分裂活性受到强烈抑制。DNA、总RNA和蛋白质合成均被抑制。然而，这些效应只有在培养基中药物浓度相对较高时才会观察到。
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