Tanaka Keiko, Nishijima Keisuke, Furuya Ken'ichi, Shin Satoko, Kai Michiaki
Graduate School Doctoral Program, Graduate School of Nursing, Department of Nursing, Oita University of Nursing and Health Sciences, Oita, Japan.
Division of Computer Science and Intelligent Systems, Faculty of Science and Technology, Oita University, Oita, Japan.
PLoS One. 2025 May 23;20(5):e0324747. doi: 10.1371/journal.pone.0324747. eCollection 2025.
The global prevalence of end-stage kidney failure is increasing, with hemodialysis as the primary treatment. An arteriovenous fistula serves as a critical lifeline for patients undergoing hemodialysis, yet its function often deteriorates due to complications such as narrowing or blockage of the blood vessels. This study aimed to clarify the relationships between the sound properties of blood flow through arteriovenous fistulas and a medical/surgical history of patients undergoing hemodialysis by analyzing the distribution of sound frequencies from 100 to 4,000 Hz. Data were collected from 53 patients to identify two key parameters: the time point within one cycle of arteriovenous fistula sounds where the power distribution reached its peak, expressed as a percentage, and the specific frequency where the power was highest within the analyzed range. The results showed that well-functioning arteriovenous fistulas exhibited peak power within the first 25 percent of the sound cycle and the highest power at 200 Hz. In contrast, higher peak percentages and lower power at 200 Hz were associated with surgical interventions due to complications such as narrowing or blockage of the arteriovenous fistula. These findings suggest that the sound properties of arteriovenous fistulas, combined with patient-specific characteristics, may serve as non-invasive indicators of arteriovenous fistula function and help predict the risk of complications. This approach provides valuable insights for improving the management of arteriovenous fistulas and patient outcomes in hemodialysis therapy.
终末期肾衰竭的全球患病率正在上升，血液透析是主要治疗方法。动静脉内瘘是接受血液透析患者的关键生命线，但其功能常因血管狭窄或堵塞等并发症而恶化。本研究旨在通过分析100至4000赫兹的声音频率分布，阐明动静脉内瘘血流声音特性与接受血液透析患者的医疗/手术史之间的关系。从53名患者收集数据以确定两个关键参数：动静脉内瘘声音一个周期内功率分布达到峰值的时间点，以百分比表示，以及分析范围内功率最高的特定频率。结果表明，功能良好的动静脉内瘘在声音周期的前25%内表现出峰值功率，在200赫兹时功率最高。相比之下，较高的峰值百分比和200赫兹时较低的功率与因动静脉内瘘狭窄或堵塞等并发症进行的手术干预有关。这些发现表明，动静脉内瘘的声音特性与患者特定特征相结合，可能作为动静脉内瘘功能的非侵入性指标，并有助于预测并发症风险。这种方法为改善动静脉内瘘管理和血液透析治疗中的患者结局提供了有价值的见解。
