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[溴隐亭对长期酒精化大鼠酒精摄入量及脑内儿茶酚胺水平的影响]

[Effect of bromocryptin on the alcohol consumption and catecholamine level in the brain of rats undergoing long-term alcoholization].

作者信息

Stanishevskaia A V, Kogan B M, Khristoliubova N A, Anokhina I P

出版信息

Farmakol Toksikol. 1985 May-Jun;48(3):88-91.

PMID:4040870
Abstract

It has been established in experiments on rats subjected to long-term alcoholization that chronic administration of bromocryptin in small doses (1 mg/kg) considerably minimizes ethanol consumption by animals. Reduction in alcoholic motivation correlates with normalization of the level of dopamine, decreased by chronic alcohol action in the rat hypothalamus and midbrain. The use of bromocryptin also prevents an increase in the dopamine content in the rat hypothalamus during alcohol withdrawal.

摘要

在对长期酒精化的大鼠进行的实验中已证实,小剂量(1毫克/千克)长期给予溴隐亭可显著减少动物的乙醇摄入量。酒精动机的降低与多巴胺水平的正常化相关,长期酒精作用使大鼠下丘脑和中脑的多巴胺水平降低。使用溴隐亭还可防止大鼠戒酒期间下丘脑多巴胺含量增加。

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