Feng Wei, Liu Huazhen, Liang Chun-Ling, Huang Haiding, Chen Yuchao, Dai Zhenhua
Immunology Program, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China; The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Immunology Program, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China; The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510006, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Int Immunopharmacol. 2025 Jun 26;159:114896. doi: 10.1016/j.intimp.2025.114896. Epub 2025 May 22.
Psoriasis is an immune-mediated inflammatory skin disease involving the activation and regulation of various immune cells. A proportion of psoriasis patients remain unresponsive to conventional therapies or targeted drugs, highlighting the urgent need for novel therapeutic strategies. In addition, although many conventional immunosuppressants are effective in the treatment of psoriasis, they may cause various side effects. Traditional Chinese Medicine (TCM) represents a potential drug candidate, with a rich history of traditional use and a vast array of pharmacological options. In particular, TCM may serve as an alternative or complementary therapy of psoriasis with potentially less side effects. In this review, we focus on immune cells, including dendritic cells, neutrophils, macrophages, myeloid-derived suppressor cells, Th17, regulatory T (Treg) cells, and γδ T cells. We provide an overview of the roles for these immune cells in the pathogenesis of psoriasis and regulatory effects of TCM and its ingredients on them. Additionally, we briefly summarize the clinical research involving treatment of psoriasis with TCM and discuss the existing challenges and limitations in this field.
银屑病是一种免疫介导的炎症性皮肤病，涉及多种免疫细胞的激活和调节。一部分银屑病患者对传统疗法或靶向药物无反应，这凸显了对新型治疗策略的迫切需求。此外，尽管许多传统免疫抑制剂在治疗银屑病方面有效，但它们可能会引起各种副作用。中药是一种潜在的候选药物，有着悠久的传统应用历史和大量的药理选择。特别是，中药可能作为银屑病的替代或补充疗法，副作用可能较小。在这篇综述中，我们重点关注免疫细胞，包括树突状细胞、中性粒细胞、巨噬细胞、髓源性抑制细胞、Th17、调节性T（Treg）细胞和γδT细胞。我们概述了这些免疫细胞在银屑病发病机制中的作用以及中药及其成分对它们的调节作用。此外，我们简要总结了涉及中药治疗银屑病的临床研究，并讨论了该领域现有的挑战和局限性。
