通过群体测序揭示的对NITD008耐药的肠道病毒71型（EV71）变异株的突变图谱。
Mutational landscapes of NITD008-resistant EV71 variants revealed through population sequencing.
作者信息
Yu Fang, Zhang Qiu-Yan, Zhang Zhe-Rui, Deng Cheng-Lin, Zhang Bo
机构信息
State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
出版信息
Virol Sin. 2025 Jun;40(3):503-505. doi: 10.1016/j.virs.2025.05.003. Epub 2025 May 21.
• The mutation spectra between WT population and NITD008-resistant populations during replication are compared. • The 2C protein may be a new target of NITD008 as a nucleotide analogue against EV71 infection. • Antiviral effect of NITD008 against EV71 is associated with increased frequency of U-to-A and U-to-C mutations.
• 比较野生型群体和NITD008抗性群体在复制过程中的突变谱。
• 2C蛋白可能作为一种核苷酸类似物成为NITD008抗EV71感染的新靶点。
• NITD008对EV71的抗病毒作用与U-to-A和U-to-C突变频率增加有关。
Zotero 插件