Imamichi S
Nihon Sanka Fujinka Gakkai Zasshi. 1985 Jul;37(7):1205-14.
A study was conducted to define biochemical characteristics of human chorionic gonadotropin (hCG) in total hydatidiform mole patients with low serum and urinary hCG levels and to inquire into the reason for its low immunological hCG level by comparing with the hCG of molar patients with a high hCG level. Both hCGs purified from chorionic tissue of molar patients with low and high hCG levels have essentially identical physicochemical, immunological and biological properties. They have low levels of biological activity and practically identical amino acid and carbohydrate compositions. It appears that moles of patients with high levels as well as those with low levels of immunoreactivity produce this purified form of hCG. Extracts of molar tissue from patients with high levels of hCG immunoreactivity also contained other substances with apparent immunoreactivity which can be found in small amounts in tissue extracts from patients who excreted low levels of hCG immunoreactivity. In contrast, extracts of molar tissue and urine from patients with low hCG levels contained hCG-like substances which cannot be detected with the ordinary commercial hCG immunoassay kits. These differences may account for the different levels excreted by these two types of patients.
开展了一项研究，以确定血清和尿液中绒毛膜促性腺激素（hCG）水平较低的完全性葡萄胎患者体内hCG的生化特征，并通过与hCG水平较高的葡萄胎患者的hCG进行比较，探究其免疫性hCG水平较低的原因。从hCG水平较低和较高的葡萄胎患者的绒毛膜组织中纯化得到的两种hCG，在物理化学、免疫和生物学特性方面基本相同。它们的生物活性水平较低，氨基酸和碳水化合物组成几乎相同。看来，免疫反应性高的患者的葡萄胎以及免疫反应性低的患者的葡萄胎都会产生这种纯化形式的hCG。hCG免疫反应性高的患者的葡萄胎组织提取物中还含有其他具有明显免疫反应性的物质，这些物质在排泄低水平hCG免疫反应性的患者的组织提取物中含量较少。相比之下，hCG水平较低的患者的葡萄胎组织和尿液提取物中含有普通商业hCG免疫检测试剂盒检测不到的hCG样物质。这些差异可能解释了这两类患者排泄水平的不同。
