Imamura S, Imamichi S, Yamabe T, Ishiguro M
Am J Obstet Gynecol. 1985 Jan 1;151(1):136-41. doi: 10.1016/0002-9378(85)90440-5.
Two glycoproteins (LM-hCG and HM-hCG) with gonadotropic activity were purified from the chorionic tissue of patients with hydatidiform mole with low and high urinary human chorionic gonadotropin levels and were compared to each other. The immunologic, biologic, and physicochemical properties of the two preparations were very similar. Also, the quantities of LM-hCG and HM-hCG recovered from molar tissue from the two types of patients were similar. However, the molar tissue from patients who excreted high levels of human chorionic gonadotropin immunoreactivity also contained other molecular forms with apparent human chorionic gonadotropin immunoreactivity tissues from patients who excreted low levels did not. These latter molecular forms may account for the differences in the levels of human chorionic gonadotropin immunoreactivity excreted by the two types of patients.
从尿中人绒毛膜促性腺激素（hCG）水平低和高的葡萄胎患者的绒毛组织中纯化出两种具有促性腺活性的糖蛋白（低分子量hCG和高分子量hCG），并对二者进行比较。两种制剂的免疫、生物学和物理化学性质非常相似。此外，从两类患者的葡萄胎组织中回收的低分子量hCG和高分子量hCG的量也相似。然而，排泄高水平hCG免疫反应性的患者的葡萄胎组织还含有其他具有明显hCG免疫反应性的分子形式，而排泄低水平hCG免疫反应性的患者的组织则没有。这些后者的分子形式可能解释了两类患者排泄的hCG免疫反应性水平的差异。
