Zeng Huanghe, Tang Lingling, Huang Li, Yang Na, Chen Xingyue, Peng Xi, Chen Zhengxian, Guo Jianxiu, Weng Jie, Guo Tailin
School of Life Sciences and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, China.
Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, Sichuan, China.
Carbohydr Polym. 2025 Aug 15;362:123636. doi: 10.1016/j.carbpol.2025.123636. Epub 2025 Apr 22.
The development of multifunctional antibacterial hydrogel dressings with enhanced mechanical properties and biological activity is essential for advancing wound healing strategies. In this study, we report the design and synthesis of a novel multifunctional hydrogel (PVA-Alg/FP), developed by integrating Fe, protocatechualdehyde (PA), polyvinyl alcohol (PVA), and sodium alginate (Alg). The hydrogel was crosslinked via multiple dynamic bonds and hydrogen bonds, avoiding the use of toxic crosslinking agents and eliminating the need for additional modification or purification steps. This approach enables the straightforward and efficient preparation of the hydrogel. The resulting hydrogel exhibits outstanding mechanical properties, with a tensile strength of 88.2 kPa. More importantly, compared with conventional PVA-Alg hydrogels crosslinked by glutaraldehyde or epichlorohydrin, our PVA-Alg/FP hydrogel demonstrates a diverse range of functional characteristics, including a high self-healing efficiency of 87.4 % within 10 min, as well as plasticity, ductility, adhesion, Deferoxamine mesylate (DFO)-responsive removal, and near-infrared (NIR) photothermal properties. Additionally, it demonstrates outstanding biocompatibility and a broad spectrum of biological activities, including antioxidant, anti-inflammatory, and antibacterial effects, as well as promoting cell migration. Furthermore, the hydrogel accelerates full-thickness skin wound healing in a Staphylococcus aureus(S.aureus)-infected rat model, providing compelling evidence of its potential as a therapeutic material for infection-induced wounds.
开发具有增强机械性能和生物活性的多功能抗菌水凝胶敷料对于推进伤口愈合策略至关重要。在本研究中，我们报告了一种新型多功能水凝胶（PVA-Alg/FP）的设计与合成，该水凝胶通过整合铁、原儿茶醛（PA）、聚乙烯醇（PVA）和海藻酸钠（Alg）而开发。该水凝胶通过多个动态键和氢键交联，避免了使用有毒交联剂，无需额外的改性或纯化步骤。这种方法能够直接且高效地制备水凝胶。所得水凝胶表现出出色的机械性能，拉伸强度为88.2 kPa。更重要的是，与通过戊二醛或环氧氯丙烷交联的传统PVA-Alg水凝胶相比，我们的PVA-Alg/FP水凝胶展示出多种功能特性，包括在10分钟内87.4%的高自愈效率，以及可塑性、延展性、粘附性、去铁胺甲磺酸盐（DFO）响应性去除和近红外（NIR）光热性能。此外，它表现出出色的生物相容性和广泛的生物活性，包括抗氧化、抗炎和抗菌作用，以及促进细胞迁移。此外，该水凝胶在金黄色葡萄球菌（S.aureus）感染的大鼠模型中加速了全层皮肤伤口愈合，为其作为感染性伤口治疗材料的潜力提供了有力证据。
