He Jiansong, Chen Jiemei, Liu Taotao, Qin Fuli, Wei Weipeng
Department of Pharmacy, The First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.
Int J Nanomedicine. 2025 Jun 16;20:7549-7578. doi: 10.2147/IJN.S519100. eCollection 2025.
Diabetic wound healing represents a crucial and complex subject in clinical medicine, because of its physiological mechanism and pathological state, the conventional treatment methods are often limited. In recent years, multifunctional hydrogels have emerged as a focal point in the research field regarding the healing of diabetic wounds. This is attributed to their outstanding biocompatibility, the capacity for controlling drug release, and the traits of facilitating cell migration and proliferation. This paper reviews the fundamental materials, modification strategies for functionality, the principles underlying drug release, and the latest application advancements of multifunctional hydrogels in the context of facilitating the healing process of diabetic wounds. By introducing bioactive molecules and utilizing 3D bioprinting technology, researchers continue to optimize the properties of hydrogels to adapt to various wound conditions, which demonstrates great promise in the use of wound dressings. Taking the microenvironment of diabetic wounds into consideration, strategies for antibacterial, anti-inflammatory, immunomodulatory, antioxidant, and pro-angiogenic effects are integrated with multifunctional hydrogels. This paper systematically analyzes the existing challenges and explores the future research directions, and emphasizes the potential of multifunctional hydrogels in improving wound healing of diabetes and their clinical application prospects.
糖尿病伤口愈合是临床医学中一个关键且复杂的课题，由于其生理机制和病理状态，传统治疗方法往往存在局限性。近年来，多功能水凝胶已成为糖尿病伤口愈合研究领域的一个焦点。这归因于它们出色的生物相容性、控制药物释放的能力以及促进细胞迁移和增殖的特性。本文综述了多功能水凝胶在促进糖尿病伤口愈合过程中的基础材料、功能改性策略、药物释放原理以及最新应用进展。通过引入生物活性分子和利用3D生物打印技术，研究人员不断优化水凝胶的性能以适应各种伤口状况，这在伤口敷料的应用中显示出巨大潜力。考虑到糖尿病伤口的微环境，抗菌、抗炎、免疫调节、抗氧化和促血管生成作用的策略与多功能水凝胶相结合。本文系统分析了现有挑战并探索了未来研究方向，强调了多功能水凝胶在改善糖尿病伤口愈合方面的潜力及其临床应用前景。
