Dynan W S, Tjian R
Nature. 1985;316(6031):774-8. doi: 10.1038/316774a0.
The enzymatic machinery that carries out RNA synthesis provides the cell with the means to adjust the patterns of transcription in response to environmental and developmental signals. In eukaryotes, this regulation is mediated in part by promoter-specific transcription factors, which are DNA-binding proteins with the ability to discriminate between distinctive DNA sequence elements found in the promoter regions of different genes. The presence of these factors bound to DNA enables other components of the transcriptional machinery, including the RNA polymerase, to initiate transcription with selectivity and accuracy.
执行RNA合成的酶机制为细胞提供了一种手段，使其能够根据环境和发育信号来调整转录模式。在真核生物中，这种调控部分是由启动子特异性转录因子介导的，这些转录因子是DNA结合蛋白，能够区分不同基因启动子区域中发现的独特DNA序列元件。这些与DNA结合的因子的存在使得转录机制的其他组分，包括RNA聚合酶，能够选择性且准确地起始转录。
