Haggerty G C, Forney R B, Johnson J M
Toxicol Appl Pharmacol. 1984 Sep 30;75(3):444-53. doi: 10.1016/0041-008x(84)90181-9.
The effects of phencyclidine (PCP) (7.0, 11.7, 19.5, 32.6, and 54.4 mg/kg) on locomotor activity, stereotyped behavior (circling, backing up, and weaving frequency), and rotarod performance were evaluated. In addition, the frequency of other PCP-induced abnormal behaviors (head in corner, arched back, and cataleptic freeze) was determined. All doses of PCP produced a significant increase in locomotor activity and stereotyped behavior as well as an impairment of rotarod performance. Both the duration and the time to peak effects (with the exception of rotarod performance) of these PCP-induced behavioral changes appeared to be dose dependent. The delay in attaining peak effects for locomotor activity and stereotypy was attributed to PCP-induced gross motor ataxia, which became more severe and long lasting with increasing dose. Although the longest period of time that significant changes were seen in locomotor activity, stereotyped behavior, and rotarod performance was 12 hr, sporadic recurrences of stereotypy and a significant increase in cataleptic freeze were observed in the high-dose groups (19.5, 32.6, and 54.4 mg/kg) up to 21 days postadministration. These persistent behaviors (stereotypy and cataleptic freeze) are not unlike certain of the prolonged behaviors seen in man with PCP overdose (catatonic stupor along with repetitive orofacial and limb movements).
评估了苯环己哌啶（PCP）（7.0、11.7、19.5、32.6和54.4毫克/千克）对运动活性、刻板行为（转圈、后退和摇摆频率）以及转棒试验表现的影响。此外，还确定了其他PCP诱导的异常行为（头靠角落、弓背和僵住不动）的频率。所有剂量的PCP均使运动活性和刻板行为显著增加，并损害了转棒试验表现。这些PCP诱导的行为变化的持续时间和达到峰值效应的时间（转棒试验表现除外）似乎都呈剂量依赖性。运动活性和刻板行为达到峰值效应的延迟归因于PCP诱导的严重运动性共济失调，随着剂量增加，这种共济失调变得更加严重且持续时间更长。尽管在运动活性、刻板行为和转棒试验表现中观察到显著变化的最长时间为12小时，但在高剂量组（19.5、32.6和54.4毫克/千克）给药后长达21天，仍观察到刻板行为的零星复发以及僵住不动的显著增加。这些持续行为（刻板行为和僵住不动）与人类PCP过量时出现的某些长期行为（紧张性木僵伴重复性口面部和肢体运动）并无不同。
