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人巨细胞病毒感染与严重口腔颌面裂发病率之间的关联：一系列罕见病例

Association between human cytomegalovirus infection and incidence of severe orofacial clefts: a series of rare cases.

作者信息

Abd-El-Ghafour Mohamed

机构信息

Department of Orthodontics, Faculty of Dentistry, Cairo University, Cairo, Egypt.

出版信息

BMC Oral Health. 2025 May 23;25(1):773. doi: 10.1186/s12903-025-06165-1.

DOI:10.1186/s12903-025-06165-1
PMID:40410786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12100889/
Abstract

BACKGROUND/OBJECTIVES: Human cytomegalovirus (HCMV) infection was scarcely reported as a prejudicing factor of CLP incidence. The aim of this study is to report an association between HCMV infection and incidence of severe orofacial clefts.

MATERIALS/METHODS: Five infants with severe orofacial clefts were included in the current study. One of the infants is with an oblique facial cleft extended to the left orbit and associated with missing left eyeball. Another infant was with facial cleft extending downward resulting in a clefted lower lip, clefted mandible and clefted tongue. All the patients' mothers were evaluated for the amount of HCMV IgG in blood samples.

RESULTS

All the five mothers of the included infants had a positive HCMV IgG results in the collected blood samples with the value of 908.8 (± 400.6). The amount of HCMV IgG was higher in cases with more severe clinical presentation.

LIMITATIONS

Due to the rarity of cases with severe orofacial clefts, only 5 patients were included. Lake of genetic data and control group are another limitations.

CONCLUSION

Within the limitation of the rareness of cases with severe orofacial clefts, HCMV infection to mothers before or during pregnancy might be a predisposing factor of incidence of severe orofacial clefts.

摘要

背景/目的：人类巨细胞病毒（HCMV）感染作为唇腭裂发病率的一个影响因素鲜有报道。本研究旨在报告HCMV感染与严重口腔颌面裂发病率之间的关联。

材料/方法：本研究纳入了5例患有严重口腔颌面裂的婴儿。其中1例婴儿患有延伸至左眼眶的斜面部裂，并伴有左眼球缺失。另1例婴儿的面部裂向下延伸，导致下唇裂开、下颌骨裂开和舌裂开。对所有患者的母亲进行血液样本中HCMV IgG含量的评估。

结果

纳入婴儿的所有5位母亲所采集血液样本中的HCMV IgG结果均为阳性，数值为908.8（±400.6）。临床表现越严重的病例，其HCMV IgG含量越高。

局限性

由于严重口腔颌面裂病例罕见，仅纳入了5例患者。缺乏基因数据和对照组是另外的局限性。

结论

在严重口腔颌面裂病例稀少的限制范围内，孕期前或孕期母亲感染HCMV可能是严重口腔颌面裂发病的一个易感因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5377/12100889/e26370ecbfe0/12903_2025_6165_Fig2_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5377/12100889/e26370ecbfe0/12903_2025_6165_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5377/12100889/312ce3742be5/12903_2025_6165_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5377/12100889/26737bb6b577/12903_2025_6165_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5377/12100889/223ac2577182/12903_2025_6165_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5377/12100889/2e7fe8ee5deb/12903_2025_6165_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5377/12100889/e26370ecbfe0/12903_2025_6165_Fig2_HTML.jpg

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本文引用的文献

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The Serological Evidence of Cytomegalovirus Infection as a Potent Aetiological Factor for Cleft Lip/Palate, Mental Retardation and Deafness.
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