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巨细胞病毒感染作为唇腭裂、智力迟钝和耳聋的潜在病因学因素的血清学证据。

The Serological Evidence of Cytomegalovirus Infection as a Potent Aetiological Factor for Cleft Lip/Palate, Mental Retardation and Deafness.

作者信息

Divya D V, Prasad Madu Ghana Shyam, Radhakrishna Ambati Naga, Reddy S Pavani, Pratyusha K, Kumar K V K Santosh, Sandeep R V

机构信息

Postgraduate Student, Department of Pedodontics and Preventive Dentistry, St. Joseph Dental College, Eluru, Andhra Pradesh, India.

Professor and Head, Department of Pedodontics and Preventive Dentistry, St. Joseph Dental College, Eluru, Andhra Pradesh, India.

出版信息

J Clin Diagn Res. 2017 Jun;11(6):ZC51-ZC54. doi: 10.7860/JCDR/2017/25118.10067. Epub 2017 Jun 1.

Abstract

INTRODUCTION

Congenital Cytomegalovirus (CCMV) infection is estimated to occur in 0.5% to 2% of all deliveries across the world. According to the available literature about Human Cytomegalovirus (HCMV) infected children, 0.5% to 1% acquire Cytomegalovirus (CMV) in utero, 40% acquire the infection within the first decade of life, between 15% to 70% acquire CMV infection in group day care settings and continue to shed the virus for 6 to 48 months after primary infection. Although, 90% of the infected infants are clinically asymptomatic at birth, shreds of evidence show that these infants are at risk for audiological, neurological, and developmental sequelae. Despite this, HCMV still remains undetected due to silent or asymptomatic nature of the virus.

AIM

The present study was aimed to test the hypothesis that HCMV can be a potential aetiologic factor in the development of cleft lip/palate, mental retardation and deafness.

MATERIALS AND METHODS

The study was carried out in a controlled setting under strict aseptic conditions. Blood samples were collected from 80 children, who were selected strictly adhering to the inclusion criteria and were divided into four groups containing 20 children each. Group 1: 20 children with cleft lip/palate, Group 2: 20 mentally retarded children, Group 3: 20 completely deaf children and Group 4: 20 normal Children (control). The samples were tested for HCMV-specific Immunoglobulin G (IgG) and Immunoglobulin M (IgM) antibodies by using solid phase enzyme-linked immunosorbent assay and the obtained data were analysed statistically using ANOVA and Post-Hoc Tukey's tests.

RESULTS

In the study group (Group1, 2 and 3) children, the overall positivity for HCMV- specific IgG was 100% and 5% borderline to IgM antibodies whereas in the control group (Group 4) it was 80% negative to HCMV- specific IgG and 100% negative to IgM antibodies.

CONCLUSION

From the observations noted in the present study, HCMV could be suggested as the potent aetiologic factor in the development of cleft lip/palate, mental retardation and deafness.

摘要

引言

据估计,全球所有分娩中先天性巨细胞病毒(CCMV)感染的发生率为0.5%至2%。根据现有关于人类巨细胞病毒(HCMV)感染儿童的文献,0.5%至1%的儿童在子宫内感染巨细胞病毒(CMV),40%的儿童在生命的第一个十年内感染,15%至70%的儿童在日托机构中感染CMV,并在初次感染后持续排毒6至48个月。虽然,90%的受感染婴儿出生时临床上无症状,但有证据表明这些婴儿有听力、神经和发育后遗症的风险。尽管如此,由于该病毒的隐匿性或无症状性,HCMV仍然未被发现。

目的

本研究旨在验证HCMV可能是唇腭裂、智力迟钝和耳聋发生的潜在病因这一假设。

材料与方法

本研究在严格无菌条件下的受控环境中进行。从80名儿童中采集血样,这些儿童严格按照纳入标准选择,并分为四组,每组20名儿童。第1组:20名唇腭裂儿童;第2组:20名智力迟钝儿童;第3组:20名完全失聪儿童;第4组:20名正常儿童(对照组)。使用固相酶联免疫吸附试验检测样本中的HCMV特异性免疫球蛋白G(IgG)和免疫球蛋白M(IgM)抗体,并使用方差分析和事后Tukey检验对获得的数据进行统计学分析。

结果

在研究组(第1、2和3组)儿童中,HCMV特异性IgG的总体阳性率为100%,IgM抗体有5%处于临界值;而在对照组(第4组)中,HCMV特异性IgG的阴性率为80%,IgM抗体的阴性率为100%。

结论

从本研究的观察结果来看,HCMV可被认为是唇腭裂、智力迟钝和耳聋发生的潜在病因。

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