Kinoshita S, Yamashita T, Yagi M, Bando H, Tsubura E, Sano T
Gan To Kagaku Ryoho. 1985 Sep;12(9):1872-6.
A 56-year-old man was admitted to our hospital with complaints of dyspnea and right pleural effusion. Malignant pleural mesothelioma was diagnosed, based on the high level of hyaluronic acid in the pleural fluid and manifestation of malignant cells by pleural needle biopsy. Anticancer chemotherapy with cisplatin and intrapleural injections of adriamycin against this mesothelioma was carried out because of the presence of stage III by Butchart's classification. Regression of the tumor, decrease of pleural fluid and decrease of LDH level in effusions were observed after this chemotherapy. Cisplatin was easily transported into the pleural fluid, and its concentration was maintained for a satisfactorily long period.
一名56岁男性因呼吸困难和右侧胸腔积液入院。根据胸腔积液中透明质酸水平升高以及胸腔穿刺活检发现恶性细胞，诊断为恶性胸膜间皮瘤。由于根据布查特分类法处于III期，因此对该间皮瘤进行了顺铂抗癌化疗及胸腔内注射阿霉素。化疗后观察到肿瘤消退、胸腔积液减少以及积液中乳酸脱氢酶水平降低。顺铂很容易转运至胸腔积液中，其浓度能在较长时间内维持在满意水平。
