Yamamoto M, Miklos G L
Chromosoma. 1977 Apr 19;60(3):283-96. doi: 10.1007/BF00329776.
We have examined the female meiotic behaviour of three X-chromosomes which have large deletions of the basal heterochromatin in Drosophila melanogaster. We find that most of this heterochromatin can be removed without substantially altering pairing and segregation of the two Xs. To compare the role of heterochromatin in male meiosis we have constructed individuals which carry two extra identical heterochromatic mini X chromosomes. These minis behave as univalents even though their heterochromatin is known to contain satellite DNA. We conclude therefore that this satellite DNA is not sufficient to allow effectively normal meiotic behaviour. In all other respects our results in the male extend and confirm Cooper's postulate that there exist specific pairing sites in the X heterochromatin. Thus we find no support in either female or male meiosis for the concenpt that satellite DNA is involved in meiotic chromosome pairing of either a chiasmate or an achiasmate kind.
我们研究了果蝇中三条X染色体的雌性减数分裂行为，这些X染色体的基部异染色质有大片段缺失。我们发现，大部分这种异染色质可以去除，而不会显著改变两条X染色体的配对和分离。为了比较异染色质在雄性减数分裂中的作用，我们构建了携带两条额外相同异染色质小X染色体的个体。这些小X染色体表现为单价染色体，尽管已知它们的异染色质含有卫星DNA。因此我们得出结论，这种卫星DNA不足以实现有效的正常减数分裂行为。在所有其他方面，我们在雄性中的研究结果扩展并证实了库珀的假设，即X异染色质中存在特定的配对位点。因此，我们在雌性或雄性减数分裂中都没有找到支持卫星DNA参与交叉型或非交叉型减数分裂染色体配对这一概念的证据。
