Grijalva C V, Kiefer S W, Gunion M W, Cooper P H, Novin D
Behav Neurosci. 1985 Feb;99(1):162-74. doi: 10.1037//0735-7044.99.1.162.
Because rats with either anterolateral neocortical or lateral hypothalamic (LH) damage initially display similar feeding and drinking deficits and recovery patterns, the possibility that anterolateral neocortical ablations would also produce similar chronic ingestive impairments to glucoprivic and hydrational challenges was examined. In general, rats with anterolateral neocortical ablations exhibited normal feeding responses to food deprivation and glucoprivation induced by insulin or moderate doses of 2-deoxy-D-glucose (2-DG), but their response to a high dose (500 mg/kg) of 2-DG was impaired. These animals also drank normally in response to hypertonic saline injections and following water deprivation, but only if food was available during the test session, results indicating that they drank prandially. Results indicate that although the anterolateral neocortex and LH are anatomically related, these brain regions appear to be functionally dissimilar in terms of the regulation of ingestion.
由于前外侧新皮层或下丘脑外侧区（LH）受损的大鼠最初表现出相似的进食和饮水缺陷及恢复模式，因此研究了前外侧新皮层切除是否也会对糖缺乏和水合挑战产生类似的慢性摄食障碍。一般来说，前外侧新皮层切除的大鼠对食物剥夺以及胰岛素或中等剂量2-脱氧-D-葡萄糖（2-DG）诱导的糖缺乏表现出正常的进食反应，但它们对高剂量（500mg/kg）2-DG的反应受损。这些动物在注射高渗盐水和禁水后也能正常饮水，但前提是在测试期间有食物，结果表明它们是在进食时饮水。结果表明，尽管前外侧新皮层和LH在解剖学上相关，但在摄食调节方面，这些脑区在功能上似乎不同。
