Guo Bei-Cyuan, Wu Han-Ping, Chen Yin-Ting, Chang Yu-Jun, Chen Chun-Yu, Lin Wen-Ya, Su Chung-Hao
Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
College of Medicine, Chang Gung University, Taoyuan, Taiwan.
BMC Pediatr. 2025 May 24;25(1):413. doi: 10.1186/s12887-025-05764-9.
Diagnosing severe bacterial infections (SBI) can be challenging, especially in infants. This study sought to identify clinical factors that could aid in predicting SBI in infants aged 91-120 days.
This retrospective cohort study investigated febrile infants aged 91-120 days admitted to the pediatric emergency department (PED). This study assessed the significant predictors of clinical and laboratory data for identifying SBI in young infants.
This study analyzed 264 febrile infants aged 91-120 days admitted to the PED. The significant factors for infants with SBI included sex, admission weight, body temperature(BT), white blood cell (WBC) count, neutrophil percentage, and C-reactive protein (CRP) level (all P < 0.05). Logistic regression analysis showed that male sex, higher BT, WBC count, and CRP levels were predictors of SBI. ROC analysis identified the useful cutoff values for predicting SBI as a BT of 39.3 °C, WBC counts of 15,500/µL, and a CRP concentration of 14.4 mg/L.
Increased BT, elevated WBC and neutrophil counts, as well as higher CRP levels, may act as predictors of SBI in infants aged 91-120 days admitted to the PED.
诊断严重细菌感染（SBI）可能具有挑战性，尤其是在婴儿中。本研究旨在确定有助于预测91至120日龄婴儿发生SBI的临床因素。
这项回顾性队列研究调查了儿科急诊科（PED）收治的91至120日龄发热婴儿。本研究评估了用于识别幼儿SBI的临床和实验室数据的重要预测因素。
本研究分析了264名PED收治的91至120日龄发热婴儿。患有SBI的婴儿的重要因素包括性别、入院体重、体温（BT）、白细胞（WBC）计数、中性粒细胞百分比和C反应蛋白（CRP）水平（均P<0.05）。逻辑回归分析表明，男性、较高的BT、WBC计数和CRP水平是SBI的预测因素。ROC分析确定预测SBI的有用临界值为BT 39.3°C、WBC计数15,500/µL和CRP浓度14.4 mg/L。
体温升高、白细胞和中性粒细胞计数升高以及CRP水平升高，可能是PED收治的91至120日龄婴儿发生SBI的预测因素。
