Lewis J P, Meyers F J, Tanaka L
Br J Haematol. 1985 Oct;61(2):261-5. doi: 10.1111/j.1365-2141.1985.tb02824.x.
Anthracyclines given by continuous infusion, as opposed to bolus administration, are associated with a reduced incidence of cardiac and gastrointestinal toxicity. Our study was developed to test the antileukaemic effect of anthracyclines given as a continuous infusion. Nineteen sequential patients admitted for treatment of acute nonlymphocytic leukaemia (ANLL) were managed with a regimen utilizing a 3 d continuous intravenous infusion of daunomycin (DNM), and the complete response rate was similar to this institution's past experience with antileukaemic regimens employing 3 d bolus DNM. In our studies, infusion DNM was at least as myelotoxic and antileukaemic as bolus DNM; thus this method of administration should be explored further in remission-induction regimens for ANLL.
与大剂量推注给药相比，持续输注蒽环类药物可降低心脏和胃肠道毒性的发生率。我们开展这项研究旨在测试持续输注蒽环类药物的抗白血病效果。19例连续收治的急性非淋巴细胞白血病（ANLL）患者采用了柔红霉素（DNM）持续静脉输注3天的方案进行治疗，完全缓解率与本机构过去使用大剂量推注DNM的抗白血病方案的经验相似。在我们的研究中，输注DNM的骨髓毒性和抗白血病作用至少与推注DNM相同；因此，这种给药方法应在ANLL的缓解诱导方案中进一步探索。
