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烧伤与长期使用阿片类药物。

Burn Injury and Long-Term Opioid Use.

作者信息

Hammond Victoria R, Keeven David D, Vacek Jonathan C, Bozeman Matthew C, Miller Keith R, Benns Matthew V

机构信息

The Hiram C. Polk, Jr. MD Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky.

The Hiram C. Polk, Jr. MD Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky.

出版信息

J Surg Res. 2025 Jul;311:106-111. doi: 10.1016/j.jss.2025.04.025. Epub 2025 May 24.

Abstract

INTRODUCTION

Exposure to opioids is a known risk factor for long-term use and dependence. The purpose of this study was to determine the prevalence of long-term prescription opioid use among burn patients after hospitalization and to identify any risk factors for long-term dependence.

METHODS

All patients admitted to a burn center during a single year period (2/1/2020-2/1/21) were examined. Deaths were excluded. A controlled substance reporting system was utilized to determine prescription opioid use from 6 mos prior to 12 mos post discharge. The duration of opioid use was examined. Long-term use was defined as active opioid prescription at 12 mos post discharge.

RESULTS

A total of 184 patients were included in the study. A total of 54.7% of patients received an opioid prescription at discharge. Seventeen patients (9.2%) had persistent opioid use at 1 year. The only independent risk factor identified for long-term opioid use was preinjury use (P < 0.001). Among the 17 patients on opioids at 1 year, 16 had filled three or more opioid prescriptions in the 6 mos prior to injury. The only patient with long-term opioid use without a pre-existing opioid history had multiple readmissions and delayed operative interventions after their initial hospital course.

CONCLUSIONS

A majority of burn patients received opioids for pain control following hospital discharge. However, the duration of therapy was generally short among opioid-naive patients. Burn injury was not associated with long-term prescription opioid use among opioid-naive patients.

摘要

引言

已知接触阿片类药物是长期使用和成瘾的风险因素。本研究的目的是确定烧伤患者住院后长期使用处方阿片类药物的患病率,并确定任何长期成瘾的风险因素。

方法

对某一年期间(2020年2月1日至2021年2月1日)入住烧伤中心的所有患者进行检查。排除死亡患者。利用受控物质报告系统确定出院前6个月至出院后12个月的处方阿片类药物使用情况。检查阿片类药物的使用时长。长期使用定义为出院后12个月仍有阿片类药物处方。

结果

本研究共纳入184例患者。共有54.7%的患者在出院时接受了阿片类药物处方。17例患者(9.2%)在1年后持续使用阿片类药物。确定的长期使用阿片类药物的唯一独立风险因素是受伤前使用(P<0.001)。在1年后仍使用阿片类药物的17例患者中,16例在受伤前6个月内开具了3张或更多阿片类药物处方。唯一一名无阿片类药物使用史却长期使用阿片类药物的患者在初次住院后多次入院且手术干预延迟。

结论

大多数烧伤患者出院后接受阿片类药物以控制疼痛。然而,在未使用过阿片类药物的患者中,治疗时间通常较短。烧伤与未使用过阿片类药物的患者长期使用处方阿片类药物无关。

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