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神经肌肉病理学中的病毒因子

Viral agents in neuromuscular pathology.

作者信息

Singh Abhay Kumar, Sudhan Yemgadda Goutham, Ramakrishna Ramakrisha, Durairajan Siva Sundara Kumar

机构信息

Department of Microbiology, School of Life Sciences, Central University of Tamil Nadu, Tiruvarur, India.

Department of Microbiology, School of Life Sciences, Central University of Tamil Nadu, Tiruvarur, India.

出版信息

Int Rev Neurobiol. 2025;180:397-434. doi: 10.1016/bs.irn.2025.04.007. Epub 2025 May 5.

DOI:10.1016/bs.irn.2025.04.007
PMID:40414639
Abstract

In recent years, viral infections have been increasingly identified as major players in neuromuscular pathologies. This chapter presents an overview of the evidence and future directions for virus-induced neuromuscular disorders. Information is integrated on the global burden of these diseases related to epidemiology, clinical features, diagnosis, treatment, and preventive strategies was integrated. Responsible viruses include enteroviruses, flaviviruses, herpesviruses, and emerging pathogens such as SARS-CoV-2. It represents a broad spectrum of neuromuscular disorders, including Guillain-Barré syndrome, viral myositis, and critical illness neuropathy/myopathy. The book chapter discusses different diagnostic approaches, therapy strategies, and rehabilitation methods, in addition to early intervention and preventive measures. This has led to new insights into novel therapies, unmet research needs, and future perspectives on viral neuromuscular disorders. This chapter demonstrates that supporting both clinical care and patient management with clinical research entails a profound understanding of the difficult interactions between the viruses concerned and the neuromuscular system.

摘要

近年来,病毒感染越来越被认为是神经肌肉疾病的主要病因。本章概述了病毒引起的神经肌肉疾病的证据及未来研究方向。整合了与这些疾病的全球负担相关的信息,涉及流行病学、临床特征、诊断、治疗及预防策略。相关病毒包括肠道病毒、黄病毒、疱疹病毒以及如SARS-CoV-2这样的新兴病原体。其涵盖了广泛的神经肌肉疾病,包括吉兰-巴雷综合征、病毒性肌炎以及危重病性神经病变/肌病。本章除了讨论早期干预和预防措施外,还探讨了不同的诊断方法、治疗策略及康复方法。这为新型疗法、未满足的研究需求以及病毒感染性神经肌肉疾病的未来前景带来了新的见解。本章表明,通过临床研究支持临床护理和患者管理需要深刻理解相关病毒与神经肌肉系统之间复杂的相互作用。

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