Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Department of Neurology, Stritch School of Medicine, Loyola University, Chicago, Illinois, USA.
Muscle Nerve. 2021 Mar;63(3):294-303. doi: 10.1002/mus.27179. Epub 2021 Jan 27.
The clinical course of neuromuscular disorders (NMDs) can be affected by infections, both in immunocompetent individuals, and in those with reduced immunocompetence due to immunosuppressive/immunomodulating therapies. Infections and immunizations may also trigger NMDs. There is a potential for reduced efficacy of immunizations in patients with reduced immunocompetence. The recent vaccination program for coronavirus disease-2019 (COVID-19) raises several questions regarding the safety and efficacy of this vaccine in individuals with NMDs. In this Practice Topic article, we address the role of vaccine-preventable infections in NMDs and the safety and efficacy of immunization in individuals with NMDs, with emphasis on vaccination against COVID-19.
神经肌肉疾病（NMDs）的临床病程可能受到感染的影响，无论是在免疫功能正常的个体中，还是在因免疫抑制/免疫调节治疗而免疫功能降低的个体中。感染和免疫接种也可能引发 NMDs。免疫功能降低的患者免疫接种的效果可能会降低。最近针对 2019 年冠状病毒病（COVID-19）的疫苗接种计划提出了一些关于该疫苗在 NMD 患者中的安全性和有效性的问题。在这篇实践专题文章中，我们讨论了可通过疫苗预防的感染在 NMD 中的作用，以及 NMD 患者免疫接种的安全性和有效性，重点是针对 COVID-19 的疫苗接种。
