医生-我应该接种 COVID-19 疫苗吗？神经肌肉疾病个体的感染与免疫
Doctor-Should I get the COVID-19 vaccine? Infection and immunization in individuals with neuromuscular disorders.
机构信息
Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Department of Neurology, Stritch School of Medicine, Loyola University, Chicago, Illinois, USA.
出版信息
Muscle Nerve. 2021 Mar;63(3):294-303. doi: 10.1002/mus.27179. Epub 2021 Jan 27.
Abstract
The clinical course of neuromuscular disorders (NMDs) can be affected by infections, both in immunocompetent individuals, and in those with reduced immunocompetence due to immunosuppressive/immunomodulating therapies. Infections and immunizations may also trigger NMDs. There is a potential for reduced efficacy of immunizations in patients with reduced immunocompetence. The recent vaccination program for coronavirus disease-2019 (COVID-19) raises several questions regarding the safety and efficacy of this vaccine in individuals with NMDs. In this Practice Topic article, we address the role of vaccine-preventable infections in NMDs and the safety and efficacy of immunization in individuals with NMDs, with emphasis on vaccination against COVID-19.
摘要
神经肌肉疾病（NMDs）的临床病程可能受到感染的影响，无论是在免疫功能正常的个体中，还是在因免疫抑制/免疫调节治疗而免疫功能降低的个体中。感染和免疫接种也可能引发 NMDs。免疫功能降低的患者免疫接种的效果可能会降低。最近针对 2019 年冠状病毒病（COVID-19）的疫苗接种计划提出了一些关于该疫苗在 NMD 患者中的安全性和有效性的问题。在这篇实践专题文章中，我们讨论了可通过疫苗预防的感染在 NMD 中的作用，以及 NMD 患者免疫接种的安全性和有效性，重点是针对 COVID-19 的疫苗接种。
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