Sugimoto Keisuke, Mochizuki Yohei, Itoi Takamasa, Tsuji Kanako, Iwano Asuka, Shimizu Yuki, Wada Yuko, Kanda Teppei
Faculty of Veterinary Medicine, Okayama University of Science, Ehime, Japan.
J Vet Med Sci. 2025 Jul 7;87(7):798-803. doi: 10.1292/jvms.25-0097. Epub 2025 May 26.
Two dogs with patent ductus arteriosus and severe pulmonary hypertension were presented to our veterinary teaching hospital. In both dogs, sildenafil was initiated to treat pulmonary hypertension, and surgery was supposed to be scheduled after dose titration. Although no obvious improvement in pulmonary hypertension was observed, no dog had polycythaemia or an increased haematocrit level. The dogs underwent ductal occlusion, and treatment with beraprost sodium was subsequently initiated. Thereafter, severe pulmonary hypertension dramatically improved. No dog showed any clinical sign of right heart failure or adverse drug reaction postoperatively, thereby demonstrating the successful treatment of two dogs with patent ductus arteriosus and severe pulmonary hypertension, using sildenafil and beraprost sodium.
两只患有动脉导管未闭和严重肺动脉高压的犬被送至我们的兽医教学医院。对于这两只犬，均开始使用西地那非治疗肺动脉高压，并计划在剂量滴定后安排手术。尽管未观察到肺动脉高压有明显改善，但两只犬均未出现红细胞增多症或血细胞比容水平升高。这两只犬接受了导管封堵术，随后开始使用贝前列素钠进行治疗。此后，严重肺动脉高压显著改善。术后，两只犬均未出现任何右心衰竭的临床症状或药物不良反应，从而证明使用西地那非和贝前列素钠成功治疗了两只患有动脉导管未闭和严重肺动脉高压的犬。
