Suzuki Ryohei, Yuchi Yunosuke, Saito Takahiro, Yasumura Yuyo, Teshima Takahiro, Matsumoto Hirotaka, Koyama Hidekazu
Laboratory of Veterinary Internal Medicine, School of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan.
Animals (Basel). 2022 Aug 15;12(16):2078. doi: 10.3390/ani12162078.
Pulmonary hypertension (PH) is a fatal condition that affects many dogs. In humans, PH is often treated with beraprost sodium (BPS). However, the effectiveness of BPS for canine PH has not been established. This study aimed to evaluate the clinical and cardiovascular response of BPS in canine patients with PH of various causes. Sixteen dogs with PH (post-capillary PH, = 8; pre-capillary PH, = 8) were included. BPS was continuously administered twice daily at 15 µg/kg. All dogs underwent echocardiography, including speckle-tracking analysis and blood pressure measurement, before and after BPS administration. Continuous BPS administration (range: 13.2-22.0 µg/kg) significantly decreased the pulmonary and systemic vascular impedance and increased left and right ventricular myocardial strain. In dogs with post-capillary PH, BPS administration caused no significant worsening of the left atrial pressure indicators. No side effects of BPS were observed in any dog. BPS also improved cardiac function and pulmonary circulation through pulmonary vasodilation, suggesting that BPS may be an additional treatment option for canine PH of various causes. Particularly, BPS increased left ventricular function and systemic circulation without worsening the left heart loading condition in dogs with post-capillary PH.
肺动脉高压（PH）是一种影响许多犬类的致命疾病。在人类中，PH通常用贝拉普罗斯钠（BPS）治疗。然而，BPS对犬类PH的有效性尚未得到证实。本研究旨在评估BPS对各种原因引起的犬类PH患者的临床和心血管反应。纳入了16只患有PH的犬（毛细血管后PH，n = 8；毛细血管前PH，n = 8）。BPS以15μg/kg的剂量每日两次连续给药。所有犬在BPS给药前后均接受了超声心动图检查，包括斑点追踪分析和血压测量。连续给予BPS（范围：13.2 - 22.0μg/kg）显著降低了肺血管和体循环血管阻抗，并增加了左、右心室心肌应变。在患有毛细血管后PH的犬中，给予BPS未导致左心房压力指标显著恶化。在任何犬中均未观察到BPS的副作用。BPS还通过肺血管舒张改善了心脏功能和肺循环，表明BPS可能是各种原因引起的犬类PH的一种额外治疗选择。特别是，BPS增加了患有毛细血管后PH的犬的左心室功能和体循环，而没有使左心负荷状况恶化。
