Brankačk Jurij, Yanovsky Yevgenij, Tort Adriano B L, Draguhn Andreas
Institute for Physiology and Pathophysiology, Heidelberg University, 69120, Heidelberg, Germany.
Brain Institute, Federal University of Rio Grande do Norte, Natal, RN, 59078-900, Brazil.
Sci Rep. 2025 May 25;15(1):18270. doi: 10.1038/s41598-025-01762-0.
Slow oscillations dominate the EEG or local field potential (LFP) of mammals during specific periods within natural sleep and anesthesia. Such similarities have led to the use of anesthesia as a model to study sleep and state-dependent changes of consciousness. Previous research has documented the similarities between the activated state of urethane anesthesia and natural REM sleep, particularly with respect to network oscillations in the theta (θ) frequency domain. Likewise, the deactivated states, characterized by large amplitude slow waves in both urethane anesthesia and non-REM sleep, have generally been regarded as similar. Here, we report striking differences between slow oscillations in the mouse parietal cortex during the deactivated state of urethane anesthesia and natural non-REM sleep. These differences are notable in the LFP, the underlying current sources, and in the modulation of unit activity. Our data show that slow network oscillations in natural sleep and anesthesia are generated by different mechanisms, despite phenomenological similarities.
在自然睡眠和麻醉的特定阶段，慢波振荡在哺乳动物的脑电图（EEG）或局部场电位（LFP）中占主导地位。这些相似之处使得麻醉被用作研究睡眠和意识状态依赖性变化的模型。先前的研究记录了氨基甲酸乙酯麻醉的激活状态与自然快速眼动睡眠之间的相似性，特别是在θ（θ）频域的网络振荡方面。同样，以氨基甲酸乙酯麻醉和非快速眼动睡眠中的大幅度慢波为特征的失活状态，通常也被认为是相似的。在这里，我们报告了在氨基甲酸乙酯麻醉的失活状态和自然非快速眼动睡眠期间，小鼠顶叶皮质慢波振荡之间的显著差异。这些差异在局部场电位、潜在电流源以及单位活动的调制方面都很明显。我们的数据表明，尽管在现象学上有相似之处，但自然睡眠和麻醉中的慢网络振荡是由不同机制产生的。
