Wang Na, Lu JiaYing, Liu XueLing, Liu JianPeng, Lu YuCheng, Xu ChengLing, Piao SiRong, Yang LiQin, Liu FengTao, Li YuXin
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Fluids Barriers CNS. 2025 May 26;22(1):52. doi: 10.1186/s12987-025-00663-8.
The choroid plexus (CP) has gained renewed attention for its role in waste clearance in neurodegenerative disorders. However, its involvement in progressive supranuclear palsy (PSP) remains unclear. This study aimed to investigate CP volume changes in patients with PSP compared to Parkinson's disease (PD), and explore its relationship with tau deposition in PSP patients.
A total of 204 participants (92 PSP, 78 PD, 34 healthy controls (HC)) underwent structural MRI, with 63 PSP patients receiving F-Florzolotau positron emission tomography. CP volume was compared across the three groups, and its ability to differentiate PSP from PD was assessed. Mean standardized uptake value ratios (SUVRs) from bilateral subcortical regions were extracted: ROIs1 including early involved nuclei of red nucleus, subthalamic nucleus, raphe nuclei, and globus pallidus; ROIs2 including late involved nuclei of substantia nigra, locus coeruleus, putamen, and thalamus. The relationship between CP volume, tau deposition and clinical assessments was analyzed.
PSP patients exhibited increased CP volume compared to PD and HC groups. The area under the curve value was 0.84 in differentiating PSP from PD, with CP volume and age as predictive variables. In the PSP group, CP volume was positively correlated with mean F-Florzolotau SUVRs in the ROIs2. Furthermore, in the PSP and PD groups, CP volume was negatively correlated with cognitive scores, but positively correlated with motor scores.
CP enlargement is a distinguishing feature of PSP and may serve as an imaging biomarker for tau accumulation, offering potential for differentiating PSP from PD.
脉络丛（CP）因其在神经退行性疾病废物清除中的作用而再次受到关注。然而，其在进行性核上性麻痹（PSP）中的作用仍不清楚。本研究旨在调查PSP患者与帕金森病（PD）患者相比脉络丛体积的变化，并探讨其与PSP患者tau蛋白沉积的关系。
共有204名参与者（92名PSP患者、78名PD患者、34名健康对照者（HC））接受了结构磁共振成像检查，其中63名PSP患者接受了F-Florzolotau正电子发射断层扫描。比较了三组的脉络丛体积，并评估了其区分PSP和PD的能力。提取双侧皮质下区域的平均标准化摄取值比率（SUVRs）：感兴趣区域1包括早期受累的红核、丘脑底核、中缝核和苍白球；感兴趣区域2包括晚期受累的黑质、蓝斑、壳核和丘脑。分析了脉络丛体积、tau蛋白沉积与临床评估之间的关系。
与PD组和HC组相比，PSP患者的脉络丛体积增加。以脉络丛体积和年龄作为预测变量，区分PSP和PD的曲线下面积值为0.84。在PSP组中，脉络丛体积与感兴趣区域2中的平均F-Florzolotau SUVRs呈正相关。此外，在PSP组和PD组中，脉络丛体积与认知评分呈负相关，但与运动评分呈正相关。
脉络丛增大是PSP的一个显著特征，可能作为tau蛋白积累的影像学生物标志物，为区分PSP和PD提供了可能。
