Lechner A J
Biol Neonate. 1985;48(1):36-42. doi: 10.1159/000242150.
The severity and permanence of growth retardation was measured in guinea pigs starved for 3 weeks with a 50% ration in late gestation (prenatal), at birth (neonatal), or at weaning. Acute and chronic effects were assessed as body mass, skeletal length, hematology, and the weight, DNA and protein contents of the hearts, the lungs, and the livers of the starved and refed animals. Organ hypoplasia was most pronounced in the prenatally starved group, and was associated with numerous stillbirths. Among survivors, catch-up growth was eventually complete. Prenatal starvation of this species provides a reproducible model of human intrauterine growth retardation, particularly of the pulmonary system.
在妊娠后期（产前）、出生时（新生儿期）或断奶时，用50%的定量对豚鼠进行为期3周的饥饿处理，以此来衡量生长发育迟缓的严重程度和持续性。通过测量饥饿及再喂养动物的体重、骨骼长度、血液学指标，以及心脏、肺和肝脏的重量、DNA和蛋白质含量，来评估急性和慢性影响。器官发育不全在产前饥饿组最为明显，且与大量死产有关。在存活者中，追赶生长最终完成。该物种的产前饥饿提供了一个可重复的人类子宫内生长迟缓模型，尤其是肺部系统的模型。
