剖宫产瘢痕妊娠子宫动脉栓塞术中动脉内注射利多卡因用于疼痛控制的安全性和有效性。
Safety and efficacy of intra-arterial lidocaine administration for pain control in uterine artery embolization for cesarean scar pregnancy.
作者信息
Cai Tianhong, Zhang Rong, Chen Kai, Deng Ting, Zhan Tenghui
机构信息
Vascular Surgery & Interventional Therapy Department, Fujian Maternity and Child Health Hospital, Fuzhou, China.
College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
出版信息
Pain Manag. 2025 Jun;15(6):325-332. doi: 10.1080/17581869.2025.2511464. Epub 2025 May 26.
BACKGROUND
Uterine artery embolization (UAE) for cesarean scar pregnancy (CSP) can cause significant pain.
OBJECTIVES
To evaluate safety and efficacy of intra-arterial lidocaine during UAE for CSP.
METHODS
Retrospective study of 255 CSP patients: Control Group (184) without lidocaine; Study Group I (39) with unilateral lidocaine; Study Group II (32) with bilateral lidocaine. Outcomes included VAS pain scores and morphine usage.
RESULTS
Early postoperative VAS scores (0-2 hours) were significantly lower in study groups ( < 0.001). No differences in later VAS scores (4-24 hours), maximal VAS scores, morphine dosage, or safety indicators.
CONCLUSION
Intra-arterial lidocaine during UAE for CSP provides effective analgesia immediately post-procedure but only for the first 2-4 hours, without reducing overall opioid requirements.
背景
剖宫产瘢痕妊娠（CSP）行子宫动脉栓塞术（UAE）可引起明显疼痛。
目的
评估在CSP的UAE过程中动脉内注射利多卡因的安全性和有效性。
方法
对255例CSP患者进行回顾性研究：对照组（184例）未使用利多卡因；研究组I（39例）单侧使用利多卡因；研究组II（32例）双侧使用利多卡因。观察指标包括视觉模拟评分法（VAS）疼痛评分和吗啡用量。
结果
研究组术后早期（0 - 2小时）VAS评分显著更低（<0.001）。后期VAS评分（4 - 24小时）、最大VAS评分、吗啡用量或安全指标无差异。
结论
CSP的UAE过程中动脉内注射利多卡因在术后即刻可提供有效的镇痛作用，但仅持续2 - 4小时，且不降低总体阿片类药物需求量。
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