Takahashi Ippei, Shinoda Genki, Ueno Fumihiko, Matsuzaki Fumiko, Noda Aoi, Murakami Keiko, Ishikuro Mami, Obara Taku, Nakayama Yoshikazu, Momose Atsushi, Tsuchiya Naho, Nagaie Satoshi, Ogishima Soichi, Tamiya Gen, Fuse Nobuo, Hozawa Atsushi, Sugawara Junichi, Kure Shigeo, Kuriyama Shinichi
Division of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Pediatr Int. 2025 Jan-Dec;67(1):e70050. doi: 10.1111/ped.70050.
Studies investigating whether respiratory syncytial virus (RSV) infection, non-RSV respiratory infections, respiratory-related disorders, and non-respiratory-related disorders are associated with subsequent wheezing are limited in Japan. We aimed to elucidate the relationship between hospitalization for RSV infection, non-RSV respiratory infections, respiratory-related disorders, as well as non-respiratory-related disorders and subsequence wheezing in Japanese children.
This study included 7340 children and was conducted under the TMM BirThree Cohort Study (Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study). Data was collected from birth records and questionnaires. We categorized hospitalization history into five categories: "no hospitalization," hospitalizations for "RSV infection," "non-RSV respiratory infections," "respiratory-related disorders," and "non-respiratory-related disorders." The association of the five categories with later wheezing at 3 years of age was evaluated using multivariable logistic regression analysis.
After adjusting for covariates, an association was shown between hospitalization under 2 years of age and later wheezing (odds ratio [OR] = 2.78; 95% confidence interval [CI] = 1.97-3.88 for "RSV infection"; OR = 2.61; 95% CI = 1.44-4.57 for "non-RSV respiratory infections"; and OR = 3.33; 95% CI = 2.43-4.54 for "respiratory-related disorders").
Hospitalization of children under 2 years of age for RSV infection as well as non-RSV respiratory infections and respiratory-related disorders were associated with subsequent wheezing.
在日本，关于呼吸道合胞病毒（RSV）感染、非RSV呼吸道感染、呼吸道相关疾病以及非呼吸道相关疾病是否与随后的喘息相关的研究有限。我们旨在阐明日本儿童因RSV感染、非RSV呼吸道感染、呼吸道相关疾病以及非呼吸道相关疾病住院与随后喘息之间的关系。
本研究纳入7340名儿童，在TMM BirThree队列研究（东北医学大数据库项目出生及三代队列研究）中进行。数据从出生记录和问卷中收集。我们将住院史分为五类：“未住院”、因“RSV感染”住院、因“非RSV呼吸道感染”住院、因“呼吸道相关疾病”住院以及因“非呼吸道相关疾病”住院。使用多变量逻辑回归分析评估这五类与3岁时随后喘息的关联。
在调整协变量后，2岁以下住院与随后的喘息之间存在关联（比值比[OR]=2.78；95%置信区间[CI]=1.97 - 3.88，“RSV感染”组；OR = 2.61；95% CI = 1.44 - 4.57，“非RSV呼吸道感染”组；OR = 3.33；95% CI = 2.43 - 4.54，“呼吸道相关疾病”组）。
2岁以下儿童因RSV感染、非RSV呼吸道感染以及呼吸道相关疾病住院与随后的喘息相关。
