比较 RSV/HRV 感染婴儿急性下呼吸道感染的临床特征，以及儿童后续喘息或哮喘的发生率。

Comparison of clinical features of acute lower respiratory tract infections in infants with RSV/HRV infection, and incidences of subsequent wheezing or asthma in childhood.

机构信息

Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

出版信息

BMC Infect Dis. 2020 May 30;20(1):387. doi: 10.1186/s12879-020-05094-4.

DOI:10.1186/s12879-020-05094-4

PMID:32473625

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7260463/

Abstract

BACKGROUND

To compare the clinical characteristics of acute lower respiratory tract infections (ALRTIs) caused by respiratory syncytial virus (RSV) and human rhinovirus (HRV) and to explore the relationship between the development of recurrent wheezing/asthma and RSV/ HRV infections in infancy.

METHODS

Retrospective study was conducted to compare the clinical characteristics of acute lower respiratory tract infections (ALRTIs). Hospitalized patients with ALRTIs from March 2007 to December 2016 were screened. Single RSV cases (s-RSV), single HRV cases (s-HRV), and cases who had co-infection with the two viruses were enrolled. Follow-up was performed to determine whether either specific respiratory virus infection was related to subsequent development of recurrent wheezing/asthma.

RESULTS

The s-RSV children were the youngest (P = 0.021), they experienced the most serious condition (P < 0.001) and respiratory failure (P < 0.001), they also required highest demand of oxygen therapy (P < 0.001). And in s-RSV group, the incidence of development of recurrent wheezing was significantly higher in subgroup with the family history of wheezing than that without (P < 0.001).

CONCLUSION

The s-RSV cases suffered from the worst severity of illness, respiratory failure and required highest demand of oxygen therapy. Recurrent wheezing was more common in s-RSV group with family history of wheezing than those without.

摘要

背景

比较呼吸道合胞病毒（RSV）和人类鼻病毒（HRV）引起的急性下呼吸道感染（ALRTIs）的临床特征，并探讨婴儿期 RSV/HRV 感染与反复喘息/哮喘发展之间的关系。

方法

采用回顾性研究比较急性下呼吸道感染（ALRTIs）的临床特征。筛选 2007 年 3 月至 2016 年 12 月住院的 ALRTIs 患者。纳入单纯 RSV 病例（s-RSV）、单纯 HRV 病例（s-HRV）和两种病毒混合感染病例。进行随访以确定特定呼吸道病毒感染是否与随后发生反复喘息/哮喘有关。