Tsukie Tamao, Kasuga Kensaku, Kikuchi Masataka, Ishiguro Takanobu, Miyashita Akinori, Onodera Osamu, Iwatsubo Takeshi, Ikeuchi Takeshi
Department of Molecular Genetics Brain Research Institute Niigata University Niigata Japan.
Department of Neurology Brain Research Institute Niigata University Niigata Japan.
Alzheimers Dement (Amst). 2025 May 23;17(2):e70125. doi: 10.1002/dad2.70125. eCollection 2025 Apr-Jun.
Previous studies have reported that cerebrospinal fluid (CSF) amyloid beta (Aβ42/Aβ38) performs comparably to Aβ42/Aβ40 in predicting amyloid positron emission tomography (PET) positivity in White cohorts. However, this finding has not been validated in diverse populations. Moreover, the utility of CSF Aβ38 in diagnosing various neurological diseases has not been fully understood.
We analyzed CSF Aβ38, Aβ40, Aβ42, phosphorylated tau181, and neurofilament light chain in Japanese research and clinical cohorts with Alzheimer's clinical syndrome (ACS) or non-ACS.
CSF Aβ42/Aβ38 predicted amyloid PET positivity comparably to Aβ42/Aβ40. The levels of CSF Aβ38 were significantly lower in patients with progressive supranuclear palsy (PSP) and idiopathic normal pressure hydrocephalus (iNPH) than in those with other diseases.
We validated the high diagnostic performance of CSF Aβ42/Aβ38 in Japanese patients with AD. CSF Aβ38 reduction may be a characteristic feature of PSP and iNPH.
The diagnostic value of cerebrospinal fluid (CSF) amyloid beta (Aβ)38 was examined in Japanese research and clinical cohorts.CSF Aβ42/Aβ38 and Aβ42/Aβ40 showed comparable performance to detect brain Aβ deposition.CSF Aβ42/Aβ38 and Aβ42/Aβ40 discordant group showed a characteristic profile.CSF Aβ38 and Aβ40 were prominently decreased in progressive supranuclear palsy and idiopathic normal pressure hydrocephalus.
先前的研究报告称，在预测白人队列中的淀粉样蛋白正电子发射断层扫描（PET）阳性方面，脑脊液（CSF）淀粉样蛋白β（Aβ42/Aβ38）的表现与Aβ42/Aβ40相当。然而，这一发现尚未在不同人群中得到验证。此外，脑脊液Aβ38在诊断各种神经系统疾病中的效用尚未完全明确。
我们分析了日本患有阿尔茨海默病临床综合征（ACS）或非ACS的研究和临床队列中的脑脊液Aβ38、Aβ40、Aβ42、磷酸化tau181和神经丝轻链。
脑脊液Aβ42/Aβ38在预测淀粉样蛋白PET阳性方面与Aβ42/Aβ40表现相当。进行性核上性麻痹（PSP）和特发性正常压力脑积水（iNPH）患者的脑脊液Aβ38水平显著低于其他疾病患者。
我们验证了脑脊液Aβ42/Aβ38在日本AD患者中的高诊断性能。脑脊液Aβ38降低可能是PSP和iNPH的一个特征。
在日本的研究和临床队列中检测了脑脊液（CSF）淀粉样蛋白β（Aβ）38的诊断价值。脑脊液Aβ42/Aβ38和Aβ42/Aβ40在检测脑Aβ沉积方面表现相当。脑脊液Aβ42/Aβ38和Aβ42/Aβ40不一致组显示出特征性特征。在进行性核上性麻痹和特发性正常压力脑积水中，脑脊液Aβ38和Aβ40显著降低。
