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源自内生真菌sp. TX-09的抗炎聚酮化合物。

Anti-inflammatory polyketides from derived endophytic fungus sp. TX-09.

作者信息

Ouyang Xin, Chen Senhua, Chen Qiling, Guo Heng, Liu Lan, Liu Hongju, Yan Chong

机构信息

School of Pharmacy, Guangdong Medical University, Dongguan, China.

School of Marine Sciences, Sun Yat-sen University, Zhuhai, China.

出版信息

Mycology. 2024 Oct 16;16(2):918-928. doi: 10.1080/21501203.2024.2397600. eCollection 2025.

DOI:10.1080/21501203.2024.2397600
PMID:40415912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12096673/
Abstract

Four new lactones, including hypomonacid A () and hypomonone A-C (), as well as nine known polyketide analogues ( and ) were obtained from endophytic fungus sp. TX-09 derived from . Their planar structures were extensively established by analysing HRESIMS and NMR spectroscopic data. Stereochemistry of new compounds was determined by X-ray diffraction analysis and modified Mosher's method in combination with quantum-chemical ECD calculation. In addition, compounds and showed anti-inflammatory activity by inhibition of lipopolysaccharide (LPS)-induced NO production in RAW264.7 cells at 50 μmol/L without cytotoxicity. Among them, compound inhibited the production of LPS-stimulated inflammation in mouse macrophage RAW264.7 cells by suppressing the expression of iNOS, TNF-α, IL-1β, and IL-6.

摘要

从来源于[具体来源未给出]的内生真菌[真菌名称未给出]TX-09中获得了四种新的内酯，包括次单酸A（[具体结构未给出]）和次单酮A - C（[具体结构未给出]），以及九种已知的聚酮类似物（[具体结构未给出]）。通过分析高分辨电喷雾电离质谱（HRESIMS）和核磁共振（NMR）光谱数据广泛确定了它们的平面结构。新化合物的立体化学通过X射线衍射分析以及改良的莫舍尔方法结合量子化学电子圆二色（ECD）计算来确定。此外，化合物[具体化合物未给出]和[具体化合物未给出]在50μmol/L时通过抑制脂多糖（LPS）诱导的RAW264.7细胞中一氧化氮（NO）的产生显示出抗炎活性且无细胞毒性。其中，化合物[具体化合物未给出]通过抑制诱导型一氧化氮合酶（iNOS）、肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）和白细胞介素-6（IL-6）的表达，抑制了LPS刺激的小鼠巨噬细胞RAW264.7细胞中的炎症产生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/45bf4d0c8aae/TMYC_A_2397600_F0011_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/987959d2513f/TMYC_A_2397600_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/46f7459e8447/TMYC_A_2397600_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/d221aaa6ac06/TMYC_A_2397600_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/17c8a733fd87/TMYC_A_2397600_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/01677e706887/TMYC_A_2397600_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/3e6ebb39dfad/TMYC_A_2397600_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/c7224d5e49a8/TMYC_A_2397600_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/dea32e1b42f7/TMYC_A_2397600_F0008_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/f156e4eb4452/TMYC_A_2397600_F0009_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/0025ddbc4df9/TMYC_A_2397600_F0010_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/45bf4d0c8aae/TMYC_A_2397600_F0011_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/987959d2513f/TMYC_A_2397600_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/46f7459e8447/TMYC_A_2397600_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/d221aaa6ac06/TMYC_A_2397600_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/17c8a733fd87/TMYC_A_2397600_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/01677e706887/TMYC_A_2397600_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/3e6ebb39dfad/TMYC_A_2397600_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/c7224d5e49a8/TMYC_A_2397600_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/dea32e1b42f7/TMYC_A_2397600_F0008_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/f156e4eb4452/TMYC_A_2397600_F0009_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/0025ddbc4df9/TMYC_A_2397600_F0010_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/12096673/45bf4d0c8aae/TMYC_A_2397600_F0011_B.jpg

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本文引用的文献

1
New bioactive secondary metabolites from fungi: 2023.来自真菌的新型生物活性次生代谢产物：2023年。
Mycology. 2024 Jun 11;15(3):283-321. doi: 10.1080/21501203.2024.2354302. eCollection 2024.
2
Shikimate-Derived Meroterpenoids from the Ascidian-Derived Fungus SYSU-MS7908 and Their Anti-Glioma Activity.来源于共生真菌 SYSU-MS7908 的莽草酸衍生倍半萜及其抗脑胶质瘤活性。
J Nat Prod. 2023 Dec 22;86(12):2651-2660. doi: 10.1021/acs.jnatprod.3c00664. Epub 2023 Nov 15.
3
Cytotoxic tetronic acid derivatives from the mangrove endophytic fungus Hypomontagnella monticulosa YX702.
从红树林内生真菌 Hypomontagnella monticulosa YX702 中分离得到细胞毒性四氢呋喃酸衍生物。
Fitoterapia. 2023 Oct;170:105656. doi: 10.1016/j.fitote.2023.105656. Epub 2023 Aug 19.
4
Integrating Genomics and Metabolomics for the Targeted Discovery of New Cyclopeptides with Antifungal Activity from a Marine-Derived Fungus .从海洋来源真菌中靶向发现具有抗真菌活性的新环肽的基因组学和代谢组学整合。
J Agric Food Chem. 2023 Jun 28;71(25):9782-9795. doi: 10.1021/acs.jafc.3c02415. Epub 2023 Jun 13.
5
Targeted Discovery of Sorbicillinoid Pigments with Anti-Inflammatory Activity from the Sponge-Derived Fungus sp. SYSU-MS7888 Using the PMG Strategy.采用PMG策略从海绵来源真菌sp. SYSU-MS7888中靶向发现具有抗炎活性的柄曲霉素类色素
J Agric Food Chem. 2022 Dec 7;70(48):15116-15125. doi: 10.1021/acs.jafc.2c05940. Epub 2022 Nov 21.
6
Plants and endophytes - a partnership for the coumarin production through the microbial systems.植物与内生菌——通过微生物系统生产香豆素的伙伴关系。
Mycology. 2022 Feb 7;13(4):243-256. doi: 10.1080/21501203.2022.2027537. eCollection 2022.
7
Anti-depressant-like effect of fermented Gastrodia elata Bl. by regulating monoamine levels and BDNF/NMDAR pathways in mice.发酵天麻通过调节小鼠单胺水平和 BDNF/NMDAR 通路产生抗抑郁样作用。
J Ethnopharmacol. 2023 Jan 30;301:115832. doi: 10.1016/j.jep.2022.115832. Epub 2022 Oct 23.
8
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9
Synthesis of sorbicillinoid analogues with anti-inflammation activities.合成具有抗炎活性的山梨醇类似物。
Bioorg Med Chem. 2022 Jan 15;54:116589. doi: 10.1016/j.bmc.2021.116589. Epub 2021 Dec 27.
10
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Nat Prod Rep. 2022 Mar 23;39(3):560-595. doi: 10.1039/d1np00041a.