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源自内生真菌sp. YD-2的生物活性萜类化合物。

Bioactive terpenoids from derived endophytic fungus sp. YD-2.

作者信息

Yan Chong, Liu Weiyang, Li Jing, Deng Yanlian, Chen Senhua, Liu Hongju

机构信息

School of Pharmacy, Guangdong Medical University Dongguan 523808 China

School of Marine Sciences, Sun Yat-Sen University Guangzhou 510275 China

出版信息

RSC Adv. 2018 Apr 19;8(27):14823-14828. doi: 10.1039/c8ra02430h. eCollection 2018 Apr 18.

DOI:10.1039/c8ra02430h
PMID:35541335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9080035/
Abstract

Two new spiromeroterpenoids, namely fusariumin A (1) and B (2), along with four known terpenoids, asperterpenoid A (3), agathic acid (4), guignardone N (5), and trametenolic acid (6), were obtained from the endophytic fungus sp. YD-2, derived from the twigs of . Their structures were elucidated by a combination of spectroscopic analyses. The absolute configuration of 1 was determined by single-crystal X-ray diffraction using Cu Kα radiation, and that of 2 was elucidated on the basis of experimental and calculated electronic circular dichroism spectra. Compound 2 exhibited moderate anti-inflammatory activity by inhibiting nitric oxide (NO) production in lipopolysaccharide activated RAW264.7 cells with an IC value of 50 μM, and compound 3 showed strong anti-inflammatory activity with an IC value of 1.6 μM. In the antibacterial assay, compound 1 displayed significant activities against and with an MIC value of 6.3 μg mL, and compound 3 showed moderate activities against and with MIC values of 6.3 and 25.2 μg mL, respectively.

摘要

从来源于[具体植物名称]嫩枝的内生真菌[真菌名称] sp. YD - 2中获得了两种新的螺环萜类化合物，即镰刀菌素A（1）和B（2），以及四种已知的萜类化合物，曲霉萜A（3）、阿加地酸（4）、吉纳多酮N（5）和云芝酸（6）。通过光谱分析相结合的方法阐明了它们的结构。1的绝对构型通过使用Cu Kα辐射的单晶X射线衍射确定，2的绝对构型基于实验和计算的电子圆二色光谱得以阐明。化合物2通过抑制脂多糖激活的RAW264.7细胞中一氧化氮（NO）的产生表现出中等抗炎活性，IC值为50 μM，化合物3表现出较强的抗炎活性，IC值为1.6 μM。在抗菌试验中，化合物1对[具体细菌名称1]和[具体细菌名称2]显示出显著活性，MIC值为6.3 μg/mL，化合物3对[具体细菌名称1]和[具体细菌名称2]分别表现出中等活性，MIC值分别为6.3和25.2 μg/mL。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc7/9080035/0d2a61d3e962/c8ra02430h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc7/9080035/d6e1905f0e2e/c8ra02430h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc7/9080035/550e1b8904d6/c8ra02430h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc7/9080035/1da90d5784f4/c8ra02430h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc7/9080035/0b65e5987232/c8ra02430h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc7/9080035/0d2a61d3e962/c8ra02430h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc7/9080035/d6e1905f0e2e/c8ra02430h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc7/9080035/550e1b8904d6/c8ra02430h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc7/9080035/1da90d5784f4/c8ra02430h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc7/9080035/0b65e5987232/c8ra02430h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc7/9080035/0d2a61d3e962/c8ra02430h-f5.jpg

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