Liu Weiyang, Chen Senhua, Li Jing, Yang Xuemei, Yan Chong, Liu Hongju
a School of Pharmacy, Guangdong Medical University , Dongguan , China.
b School of Marine Sciences, Sun Yat-Sen University , Guangzhou , China.
Nat Prod Res. 2019 Feb;33(3):354-359. doi: 10.1080/14786419.2018.1452003. Epub 2018 Mar 19.
A new β-tetralonyl glucoside, methylberchemiaside (1), along with five known compounds (2-6) were isolated from a fungus Colletotrichum sp . GDMU-1 derived from the leaves of Santalum album. Their structures were determined by detailed analysis of spectroscopic data. All compounds were tested for the inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-treated RAW264.7 cells. Among them, compounds 4 and 5 showed moderate anti-inflammatory activity with IC value of 30.4 and 8.9 μM, respectively.
从檀香叶来源的炭疽菌属真菌GDMU-1中分离得到一个新的β-四丙二酰基葡萄糖苷——甲基百蕊草苷（1）以及5个已知化合物（2-6）。通过对光谱数据的详细分析确定了它们的结构。对所有化合物进行了测试，考察其对脂多糖（LPS）刺激的RAW264.7细胞中一氧化氮（NO）生成的抑制作用。其中，化合物4和5表现出中等程度的抗炎活性，IC50值分别为30.4和8.9 μM。
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