血清尿酸水平与血脂异常10年预期风险之间的关联：来自健康心脏项目（YHHP）的队列研究

The Association Between Serum Uric Acid Levels and the 10-Year Prospective Risk of Dyslipidemia: A Cohort Study From Healthy Heart Project (YHHP).

作者信息

Mohammadi Hamidreza, Mirjalili Seyed Reza, Marques-Vidal Pedro Manuel, Azimizadeh Marzieh, Nemayandah Seyede Mahdiah, Sarebanhassanabadi Mohammadtaghi, Sadeghi Sedighe

机构信息

Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute Shahid Sadoughi University of Medical Sciences Yazd Iran.

Department of Medicine, Internal Medicine Lausanne University Hospital and University of Lausanne Lausanne Switzerland.

出版信息

Health Sci Rep. 2025 May 22;8(5):e70857. doi: 10.1002/hsr2.70857. eCollection 2025 May.

DOI:10.1002/hsr2.70857

PMID:40415978

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12098965/

Abstract

BACKGROUND AND AIMS

Dyslipidemia is a major risk factor for cardiovascular disease (CVD) and is increasingly prevalent globally, particularly in developing countries undergoing lifestyle transitions. Serum uric acid (SUA) has been implicated in various metabolic disorders, including dyslipidemia. This study aimed to evaluate the association between high SUA and the 10-year prospective risk of dyslipidemia.

METHODS

This cohort study uses data from the Yazd Healthy Heart Project (YHHP). Participants were followed for 10 years, during which the association between dyslipidemia incidence and SUA levels was assessed using multivariate Cox proportional hazard models.

RESULTS

Among 693 participants analyzed, higher SUA quartiles were associated with older age, male gender, and adverse anthropometric and metabolic profiles. Elevated SUA levels correlated positively with triglycerides ( = 0.21, < 0.001), total ( = 0.13, < 0.001) and low-density lipoprotein cholesterol ( = 0.12, = 0.001) levels, but not with high-density lipoprotein cholesterol ( = 0.07, > 0.05). After adjusting for age, lifestyle factors, and metabolic parameters, the incidence of dyslipidemia increased across SUA quartiles in males, with adjusted hazard ratios of 1.33 (95% CI: 0.90-1.97), 1.66 (95% CI: 1.10-2.54), and 1.79 (95% CI: 1.17-2.72) for the second, third, and fourth quartiles of SUA, respectively ( for trend 0.001), but not in females: 1.11 (95% CI: 0.59-2.06), 0.95 (95% CI: 0.55-1.64), and 1.14 (95% CI: 0.60-2.16), respectively, for trend 0.86.

CONCLUSION

Elevated SUA levels independently associated with the development of dyslipidemia over a decade in an Iranian population. The findings underscore the potential utility of SUA as a biomarker for assessing dyslipidemia risk, particularly in men. Further research should explore mechanistic pathways linking SUA to dyslipidemia and evaluate interventions targeting SUA reduction to mitigate dyslipidemia risk.

摘要

背景与目的

血脂异常是心血管疾病（CVD）的主要危险因素，在全球范围内日益普遍，尤其是在经历生活方式转变的发展中国家。血清尿酸（SUA）与包括血脂异常在内的各种代谢紊乱有关。本研究旨在评估高SUA水平与血脂异常10年的前瞻性风险之间的关联。

方法

本队列研究使用了亚兹德健康心脏项目（YHHP）的数据。对参与者进行了10年的随访，在此期间，使用多变量Cox比例风险模型评估血脂异常发病率与SUA水平之间的关联。

结果

在分析的693名参与者中，较高的SUA四分位数与年龄较大、男性性别以及不良的人体测量和代谢特征相关。SUA水平升高与甘油三酯（r = 0.21，P < 0.001）、总胆固醇（r = 0.13，P < 0.001）和低密度脂蛋白胆固醇（r = 0.12，P = 0.001）水平呈正相关，但与高密度脂蛋白胆固醇（r = 0.07，P > 0.05）无关。在调整年龄、生活方式因素和代谢参数后，男性中血脂异常的发病率随着SUA四分位数的增加而增加，SUA第二、第三和第四四分位数的调整后风险比分别为1.33（95%CI：0.90 - 1.97）、1.66（95%CI：1.10 - 2.54）和1.79（95%CI：1.17 - 2.72）（趋势P = 0.001），但在女性中并非如此：分别为1.11（95%CI：0.59 - 2.06）、0.95（95%CI：0.55 - 1.64）和1.14（95%CI：0.60 - 2.16），趋势P = 0.86。