探究孟加拉国年轻成年人血清尿酸与血脂异常之间的关系。

Investigating the Relationship Between Serum Uric Acid and Dyslipidemia in Young Adults in Bangladesh.

作者信息

Taher Abu, Trisha Aporajita Das, Ahmed Shamim, Begum Jannat, Sinha Falguni, Sarna Nusrat Zaman, Ali Nurshad

机构信息

Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh.

出版信息

Endocrinol Diabetes Metab. 2025 May;8(3):e70063. doi: 10.1002/edm2.70063.

DOI:10.1002/edm2.70063

PMID:40420797

Abstract

OBJECTIVES

While some reports exist on the relationship between serum uric acid (SUA) and dyslipidemia in adults, there is limited information available regarding young adults. This study aimed to evaluate the relationship between SUA and dyslipidemia, as well as its components, among young adults in Bangladesh.

METHODS

This study consisted of 458 participants (281 male and 177 female) aged between 18 and 30 years. The levels of SUA, fasting blood glucose and lipid profile (TG, TC, HDL-C and LDL-C) were measured using standard colorimetric methods. Bivariate logistic regression modelling was used to examine the relationship between SUA and dyslipidemia and its components.

RESULTS

The overall prevalence of hyperuricemia was 24% with 27.6% in males and 18.6% in females. Males had a higher mean SUA level (6.6 ± 1.5 mg/dL) than females (5.3 ± 1.2 mg/dL) (p < 0.001). The prevalence of dyslipidemia was 74.2% with 83.2% in male and 59.8% in female subjects. The prevalence of hypertriglyceridemia, hypercholesterolemia, high LDL-C and low HDL-C was 30.1%, 26.2%, 28.8% and 64.8%, respectively. There was an increasing trend in the level and prevalence of elevated lipid profile markers across the SUA quartiles (p < 0.001). SUA level showed a positive correlation with TG, TC and LDL-C and a negative correlation with HDL (p < 0.001). In regression analysis, a significant association was found between SUA and dyslipidemia in all participants as well as in the male-female groups separately (at least p < 0.05). Furthermore, a significant association (p < 0.001) was found between SUA and individual lipid components in the regression models.

CONCLUSION

Dyslipidemia and its components were more prevalent in individuals with hyperuricemia than in those without. This study identified a significant association between SUA and dyslipidemia in young adults in Bangladesh. Further research is needed to explore the mechanisms behind this association.

摘要

目的

虽然有一些关于成人血清尿酸（SUA）与血脂异常之间关系的报道，但关于年轻人的信息有限。本研究旨在评估孟加拉国年轻人中SUA与血脂异常及其各组分之间的关系。

方法

本研究纳入了458名年龄在18至30岁之间的参与者（281名男性和177名女性）。使用标准比色法测量SUA、空腹血糖和血脂谱（甘油三酯、总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇）水平。采用二元逻辑回归模型来研究SUA与血脂异常及其各组分之间的关系。

结果

高尿酸血症的总体患病率为24%，男性为27.6%，女性为18.6%。男性的平均SUA水平（6.6±1.5mg/dL）高于女性（5.3±1.2mg/dL）（p<0.001）。血脂异常的患病率为74.2%，男性为83.2%，女性为59.8%。高甘油三酯血症、高胆固醇血症、高LDL-C和低HDL-C的患病率分别为30.1%、26.2%、28.8%和64.8%。在SUA四分位数中，血脂谱标志物水平和患病率呈上升趋势（p<0.001）。SUA水平与甘油三酯、总胆固醇和低密度脂蛋白胆固醇呈正相关，与高密度脂蛋白呈负相关（p<0.001）。在回归分析中，在所有参与者以及男性和女性组中均发现SUA与血脂异常之间存在显著关联（至少p<0.05）。此外，在回归模型中发现SUA与个体脂质组分之间存在显著关联（p<0.001）。