[使用羟丁酸钠对制动应激进行药物纠正期间外周儿茶酚胺能系统的状态]
[State of the peripheral catecholaminergic systems during pharmacologic correction of immobilization stress using sodium oxybutyrate].
作者信息
Khaĭsman E B, Malikova L A, Arefolov V A
出版信息
Biull Eksp Biol Med. 1985 Sep;100(9):317-9.
Fluorescent microscopy and spectrofluorometry of biogenic amines were employed to study the peripheral catecholaminergic systems in immobilized rats which received sodium hydroxybutyrate. The content of catecholamines was measured in the adrenergic nerves of dura mater, vas deferens and chromaffin tissue of the adrenals. It was established that sodium hydroxybutyrate in a dose of 40 mg/kg intraperitoneally promoted returning to normal of the adrenergic mediator activity during alarm and resistance stages. The role of the peripheral catecholaminergic systems in the mechanism of the stress-protective effect of sodium hydroxybutyrate is discussed.
采用生物胺的荧光显微镜和荧光分光光度法，研究了腹腔注射羟基丁酸钠的固定大鼠的外周儿茶酚胺能系统。测定了硬脑膜、输精管和肾上腺嗜铬组织的肾上腺素能神经中儿茶酚胺的含量。结果表明，腹腔注射40mg/kg剂量的羟基丁酸钠可促进警戒期和抵抗期肾上腺素能介质活性恢复正常。并讨论了外周儿茶酚胺能系统在羟基丁酸钠应激保护作用机制中的作用。
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