Bershteĭn L M, Kovaleva I G, Rozenberg O A
Biull Eksp Biol Med. 1985 Sep;100(9):334-6.
A study was made of the action of the antidiabetic biguanide phenformin, clofibrate and the phospholipid drug Essentiale on the basal and adrenaline-stimulated activity of adenylate cyclase in Ehrlich's ascites carcinoma cells. All the drugs under study potentiated the hormone-stimulated activity of adenylate cyclase. Unlike phenformin and Essentiale, clofibrate did not exert any effect on the basal activity of adenylate cyclase. On the other hand, certain differences were revealed in changes of the lipid content of tumor cells during application of the drugs in question. Stimulation of adenylate cyclase activity by hypolipidemic drugs is regarded as a promising approach to the goal-oriented changing of hormonal sensitivity of tumor cells.
研究了抗糖尿病双胍类药物苯乙双胍、氯贝丁酯和磷脂药物易善力对艾氏腹水癌细胞中腺苷酸环化酶基础活性和肾上腺素刺激活性的作用。所有研究的药物均增强了激素刺激的腺苷酸环化酶活性。与苯乙双胍和易善力不同，氯贝丁酯对腺苷酸环化酶的基础活性没有任何影响。另一方面，在应用上述药物期间，肿瘤细胞脂质含量的变化显示出某些差异。降血脂药物对腺苷酸环化酶活性的刺激被认为是一种有前景的方法，可用于有针对性地改变肿瘤细胞的激素敏感性。
