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The Influence of Trinucleotide Repeats in the Androgen Receptor Gene and Testosterone Level on Circulating Proteins in Male Participants: Proteomics Analysis Using the UK Biobank Data.

作者信息

Sasako Takayoshi, Ilboudo Yann, Chen Yiheng, Liang Kevin Y H, Yoshiji Satoshi, Richards J Brent

机构信息

McGill University, Montréal, Canada.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada.

出版信息

JMA J. 2025 Apr 28;8(2):591-595. doi: 10.31662/jmaj.2024-0340. Epub 2025 Apr 4.

DOI:10.31662/jmaj.2024-0340
PMID:40416043
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12095775/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5f3/12095775/f5d4f2b8c7af/2433-3298-8-2-0591-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5f3/12095775/f5d4f2b8c7af/2433-3298-8-2-0591-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5f3/12095775/f5d4f2b8c7af/2433-3298-8-2-0591-g001.jpg

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本文引用的文献

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Integrative proteogenomic analysis identifies COL6A3-derived endotrophin as a mediator of the effect of obesity on coronary artery disease.整合蛋白质基因组分析确定COL6A3衍生的内营养素是肥胖对冠状动脉疾病影响的介质。
Nat Genet. 2025 Feb;57(2):345-357. doi: 10.1038/s41588-024-02052-7. Epub 2025 Jan 24.
2
The Influence of Trinucleotide Repeats in the Androgen Receptor Gene on Androgen-related Traits and Diseases.雄激素受体基因三核苷酸重复对雄激素相关特征和疾病的影响。
J Clin Endocrinol Metab. 2024 Nov 18;109(12):3234-3244. doi: 10.1210/clinem/dgae302.
3
Plasma proteomic associations with genetics and health in the UK Biobank.
英国生物库中血浆蛋白质组与遗传学和健康的关联。
Nature. 2023 Oct;622(7982):329-338. doi: 10.1038/s41586-023-06592-6. Epub 2023 Oct 4.
4
Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.血浆代谢组学基因组图谱优先考虑与人类疾病相关的代谢物。
Nat Genet. 2023 Jan;55(1):44-53. doi: 10.1038/s41588-022-01270-1. Epub 2023 Jan 12.
5
Severe aortic stenosis during leptin replacement therapy in a patient with generalized lipodystrophy-associated progeroid syndrome due to an LMNA variant: A case report.患者患有全身性脂肪营养不良相关早老综合征,由于 LMNA 变异导致瘦素替代治疗期间出现严重主动脉瓣狭窄:病例报告。
J Diabetes Investig. 2022 Sep;13(9):1636-1638. doi: 10.1111/jdi.13827. Epub 2022 Jun 10.
6
Dihydrotestosterone potentiates insulin to up-regulate prokineticin-1 in decidualizing human endometrial stromal cells.二氢睾酮增强胰岛素作用上调人子宫内膜基质细胞中促动力素-1 的表达。
J Cell Mol Med. 2020 Mar;24(5):3242-3245. doi: 10.1111/jcmm.14923. Epub 2020 Jan 28.
7
Emerging role of testosterone in pancreatic β-cell function and insulin secretion.睾酮在胰腺β细胞功能和胰岛素分泌中的新作用。
J Endocrinol. 2019 Jan 1. doi: 10.1530/JOE-18-0573.
8
The Anti-Inflammatory Effects of Testosterone.睾酮的抗炎作用
J Endocr Soc. 2018 Oct 22;3(1):91-107. doi: 10.1210/js.2018-00186. eCollection 2019 Jan 1.
9
The UK Biobank resource with deep phenotyping and genomic data.英国生物银行资源库,具有深度表型和基因组数据。
Nature. 2018 Oct;562(7726):203-209. doi: 10.1038/s41586-018-0579-z. Epub 2018 Oct 10.
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Detection of long repeat expansions from PCR-free whole-genome sequence data.从无 PCR 全基因组序列数据中检测长重复扩展。
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