Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Department of Gynecology and Reproductive Medicine, Karolinska University Hospital, Stockholm, Sweden.
J Cell Mol Med. 2020 Mar;24(5):3242-3245. doi: 10.1111/jcmm.14923. Epub 2020 Jan 28.
Prokineticin 1 (PROK1) is a key regulator of embryo implantation and placentation, and its dysregulation is associated with pregnancy complications, such as pre-eclampsia and foetal growth restriction. We have previously shown that insulin strongly enhances the expression of PROK1 in human decidualizing stromal cells. Here, we demonstrate that dihydrotestosterone (DHT), but not testosterone, potentiates insulin to up-regulate PROK1 in these cells. However, the androgens alone do not influence the expression of PROK1. Our findings suggest that insulin and androgens both are involved in the regulation of PROK1 that could have implications for normal and pathological pregnancies.
原动蛋白 1（PROK1）是胚胎着床和胎盘形成的关键调节因子，其失调与妊娠并发症有关，如子痫前期和胎儿生长受限。我们之前已经表明，胰岛素强烈增强人蜕膜化基质细胞中 PROK1 的表达。在这里，我们证明二氢睾酮（DHT）而不是睾酮增强胰岛素上调这些细胞中的 PROK1。然而，单独的雄激素并不影响 PROK1 的表达。我们的发现表明，胰岛素和雄激素都参与 PROK1 的调节，这可能对正常和病理性妊娠有影响。
