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靶向牙源性角化囊肿：5-氟尿嘧啶通过抑制胸苷酸合成酶的治疗潜力。

Targeting the Odontogenic Keratocysts: Therapeutic Potential of 5-Fluorouracil Through Thymidylate Synthase Inhibition.

作者信息

Reddy G V, Reddy G Siva Prasada, Priyatham Vishnu, Veeravalli John Jims, Kocherlakota Srimounica

机构信息

Department of Oral and Maxillofacial Surgery, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Hyderabad, IND.

出版信息

Cureus. 2025 Apr 24;17(4):e82905. doi: 10.7759/cureus.82905. eCollection 2025 Apr.

DOI:10.7759/cureus.82905
PMID:40416148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12103102/
Abstract

Odontogenic keratocysts (OKCs) are aggressive cystic lesions of the jaw with a high recurrence rate. They are benign lesions that arise from dental lamina remnants or basal cells of the overlying epithelium. Various surgical and adjunctive treatments have been explored to minimize recurrence. In this report, we review the literature elucidating the efficacy of 5-fluorouracil (5-FU) topical application for recurrent OKCs and discuss the management of an OKC with 5-FU after enucleation and a 12-month follow-up.

摘要

牙源性角化囊肿（OKCs）是颌骨的侵袭性囊性病变，复发率高。它们是由牙板残余或覆盖上皮的基底细胞产生的良性病变。已经探索了各种手术和辅助治疗方法以尽量减少复发。在本报告中，我们回顾了阐明5-氟尿嘧啶（5-FU）局部应用于复发性OKCs疗效的文献，并讨论了摘除术后用5-FU治疗OKC并进行12个月随访的情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/c507eb9086d6/cureus-0017-00000082905-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/67409e92ca22/cureus-0017-00000082905-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/3d2fb5ae4864/cureus-0017-00000082905-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/80138f4b9e78/cureus-0017-00000082905-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/2207b43fbcc8/cureus-0017-00000082905-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/a6d4bb72561d/cureus-0017-00000082905-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/de44728d9355/cureus-0017-00000082905-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/8e2b9e285a2a/cureus-0017-00000082905-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/9c63189c5ba7/cureus-0017-00000082905-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/bdc0892c7dde/cureus-0017-00000082905-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/c507eb9086d6/cureus-0017-00000082905-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/67409e92ca22/cureus-0017-00000082905-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/3d2fb5ae4864/cureus-0017-00000082905-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/80138f4b9e78/cureus-0017-00000082905-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/2207b43fbcc8/cureus-0017-00000082905-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/a6d4bb72561d/cureus-0017-00000082905-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/de44728d9355/cureus-0017-00000082905-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/8e2b9e285a2a/cureus-0017-00000082905-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/9c63189c5ba7/cureus-0017-00000082905-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/bdc0892c7dde/cureus-0017-00000082905-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/12103102/c507eb9086d6/cureus-0017-00000082905-i10.jpg

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本文引用的文献

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Healthcare (Basel). 2023 Feb 1;11(3):416. doi: 10.3390/healthcare11030416.
2
5-Fluorouracil Is Associated With a Decreased Recurrence Risk in Odontogenic Keratocyst Management: A Retrospective Cohort Study.5-氟尿嘧啶治疗牙源性角化囊性瘤降低复发风险：一项回顾性队列研究。
J Oral Maxillofac Surg. 2021 Apr;79(4):814-821. doi: 10.1016/j.joms.2020.07.215. Epub 2020 Aug 5.
3
Topical 5-fluorouracil application in management of odontogenic keratocysts.
局部应用5-氟尿嘧啶治疗牙源性角化囊肿
J Oral Biol Craniofac Res. 2020 Oct-Dec;10(4):404-406. doi: 10.1016/j.jobcr.2020.07.008. Epub 2020 Jul 22.
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Recurrence of odontogenic keratocysts and possible prognostic factors: Review of 455 patients.牙源性角化囊肿的复发和可能的预后因素：455 例患者的回顾性研究。
Med Oral Patol Oral Cir Bucal. 2019 Jul 1;24(4):e491-e501. doi: 10.4317/medoral.22827.
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The fourth edition of the head and neck World Health Organization blue book: editors' perspectives.《世界卫生组织头颈部蓝皮书》第四版：编辑观点
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Topical 5-Fluorouracil is a Novel Targeted Therapy for the Keratocystic Odontogenic Tumor.局部应用5-氟尿嘧啶是牙源性角化囊性瘤的一种新型靶向治疗方法。
J Oral Maxillofac Surg. 2017 Mar;75(3):514-524. doi: 10.1016/j.joms.2016.09.039. Epub 2016 Sep 30.
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Vismodegib hedgehog-signaling inhibition and treatment of basal cell carcinomas as well as keratocystic odontogenic tumors in Gorlin syndrome.维莫德吉抑制Hedgehog信号通路及治疗基底细胞癌和戈林综合征中的牙源性角化囊性瘤。
Ann Maxillofac Surg. 2015 Jan-Jun;5(1):14-9. doi: 10.4103/2231-0746.161049.
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J Oral Maxillofac Surg. 2015 Nov;73(11):2132-5. doi: 10.1016/j.joms.2015.05.005. Epub 2015 May 20.
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