Chen Yang-Tao, Wei Can-Jie, Wang Zhao-Chu, Xie Ya-Meng, Wang Xun, Wang Jing
Department of Anorectal Surgery, The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Front Nutr. 2025 May 9;12:1537644. doi: 10.3389/fnut.2025.1537644. eCollection 2025.
The objective was to evaluate ABSI's association with depression and explore FBG as a possible mediating factor.
Data from 8,748 NHANES participants (2017-2023) were analyzed. Logistic regression analyses assessed ABSI-depression associations, while mediation models tested FBG's intermediary role. We conducted stratified analyses and interaction test to assess the impact of gender, age, race, PIR, education, alcohol use, current smoking status, BMI, hypertension history and hypercholesterolemia history on the study outcomes.
The fully adjusted logistic regression models demonstrated a significant positive association between ABSI and depression (OR = 1.20, 95%CI: 1.00, 1.44, = 0.0497). Stratified analyses and interaction test showed that this association was significant only among participants with some college education or above (P for interaction < 0.05). No significant interactions were found across other subgroups. Mediation analyses revealed that FBG partially mediated the relationship between ABSI and depression (15.8%, < 0.0001).
ABSI was associated with depression, potentially mediated through FBG.
评估体脂率指数（ABSI）与抑郁症之间的关联，并探讨空腹血糖（FBG）作为可能的中介因素。
分析了来自8748名美国国家健康与营养检查调查（NHANES，2017 - 2023年）参与者的数据。逻辑回归分析评估ABSI与抑郁症之间的关联，而中介模型则检验FBG的中介作用。我们进行了分层分析和交互作用检验，以评估性别、年龄、种族、贫困收入比（PIR）、教育程度、饮酒情况、当前吸烟状况、体重指数（BMI）、高血压病史和高胆固醇血症病史对研究结果的影响。
经过充分调整的逻辑回归模型显示，ABSI与抑郁症之间存在显著的正相关（比值比[OR] = 1.20，95%置信区间[CI]：1.00，1.44，P = 0.0497）。分层分析和交互作用检验表明，这种关联仅在接受过一些大学教育及以上的参与者中显著（交互作用P < 0.05）。在其他亚组中未发现显著的交互作用。中介分析显示，FBG部分介导了ABSI与抑郁症之间的关系（15.8%，P < 0.0001）。
ABSI与抑郁症相关，可能通过FBG介导。
