Sarwar Shahzad, Leong Gary, Liu Anthony, Bhurawala Habib
Department of Paediatrics, Nepean Hospital, Kingswood, New South Wales, Australia.
Department of Endocrinology and Diabetes, Nepean Hospital, Kingswood, New South Wales, Australia.
J ASEAN Fed Endocr Soc. 2025 May;40(1):14-19. doi: 10.15605/jafes.040.01.02. Epub 2024 Apr 29.
To report the incidence and clinical characteristics of paediatric patients presenting with diabetic ketoacidosis to the Emergency Department (ED) with new and pre-existing type 1 diabetes mellitus (T1DM).
A ten-year retrospective data analysis was performed on children under 16 years presenting to the ED with T1DM from January 2010. Demographic and laboratory data were extracted to determine the rates of DKA. Comparative statistics were performed between age groups and pre-existing and newly diagnosed T1DM patients.
A total of 196 children with T1DM were included. The mean age of the cohort was 9.3 ± 4.0 years, with female predominance (54%, = 0.38). Most (60%) were newly diagnosed with T1DM, of which 38% presented in DKA. Amongst the total cohort, 43% presented in DKA.The older children accounted for 50% of the DKA presentations in the newly diagnosed cohort. Amongst the younger age group, 42% presented with severe DKA. There were higher rates of T1DM in areas of relative socioeconomic advantage.
Children with T1DM presented with unacceptably high rates of DKA and posed a significant medical, psychosocial and financial burden on families and medical services. These findings suggest that a prospective public health campaign to reduce rates of DKA is warranted.
报告患有糖尿病酮症酸中毒的1型糖尿病(T1DM)新发病例及既往病例的儿科患者前往急诊科(ED)就诊的发病率和临床特征。
对2010年1月起前往急诊科就诊的16岁以下T1DM儿童进行了为期十年的回顾性数据分析。提取人口统计学和实验室数据以确定糖尿病酮症酸中毒(DKA)的发生率。对不同年龄组以及T1DM既往病例和新诊断病例进行了比较统计分析。
共纳入196例T1DM儿童。队列的平均年龄为9.3±4.0岁,女性占优势(54%,P = 0.38)。大多数(60%)为新诊断的T1DM,其中38%以DKA形式就诊。在整个队列中,43%以DKA形式就诊。年龄较大的儿童占新诊断队列中DKA病例的50%。在较年轻的年龄组中,42%表现为重度DKA。在社会经济相对发达地区,T1DM的发病率较高。
T1DM儿童中DKA的发病率高得令人难以接受,给家庭和医疗服务带来了重大的医疗、心理社会和经济负担。这些发现表明有必要开展一项前瞻性公共卫生运动以降低DKA的发病率。