Faculty of Medicine, Cairo University, Cairo, Egypt.
Ain Shams University Faculty of Medicine, Cairo, Egypt.
Pediatr Res. 2023 Apr;93(5):1149-1160. doi: 10.1038/s41390-022-02241-2. Epub 2022 Aug 11.
Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of type 1 diabetes mellitus (T1DM) that has increased during the COVID-19 pandemic. This study will not only shed light on such life-threatening complications but also be a step to increase the awareness of healthcare providers about such complications in the upcoming pandemic waves and increased dependence on telemedicine. Thus, we aimed to further investigate the increase of DKA in pediatrics.
PubMed, Web of Science, and Scopus were broadly searched for studies assessing the incidence of DKA in pediatrics during the COVID-19 pandemic.
Our study included 24 papers with a total of 124,597 children with diabetes. A statistically significant increase occurred in the risk of DKA among newly diagnosed T1DM patients during the pandemic (RR 1.41; 95% CI 1.19, 1.67; p < 0.01; I = 86%), especially in the severe form of DKA (RR 1.66: 95% CI 1.3, 2.11) when compared to before.
DKA in newly diagnosed children with T1DM has increased during the pandemic and presented with a severe form. This may reflect that COVID-19 may have contributed not only to the development but also the severity of DKA.
Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes mellitus (T1DM) that has increased during the COVID-19 pandemic. Our study included 25 papers with a total of 124,597 children with diabetes. A statistically significant increase occurred in the risk of DKA among newly diagnosed T1DM patients during the pandemic. Our findings reflect that COVID-19 may have an altered presentation in T1DM and can be related to DKA severity.
糖尿病酮症酸中毒（DKA）是 1 型糖尿病（T1DM）的一种潜在危及生命的并发症，在 COVID-19 大流行期间有所增加。本研究不仅将阐明此类危及生命的并发症，而且将有助于提高医疗保健提供者对即将到来的大流行浪潮和对远程医疗的日益依赖中此类并发症的认识。因此，我们旨在进一步研究儿科 DKA 的增加情况。
广泛检索了 PubMed、Web of Science 和 Scopus 中评估 COVID-19 大流行期间儿科 DKA 发病率的研究。
我们的研究纳入了 24 篇论文，共纳入了 124597 名糖尿病儿童。与之前相比，大流行期间新发 T1DM 患者发生 DKA 的风险呈统计学显著增加（RR 1.41；95%CI 1.19，1.67；p<0.01；I=86%），尤其是 DKA 严重程度（RR 1.66：95%CI 1.3，2.11）。
大流行期间新发 T1DM 儿童的 DKA 增加，并呈现严重程度。这可能反映出 COVID-19 不仅促成了 DKA 的发生，而且还加重了其严重程度。
糖尿病酮症酸中毒（DKA）是 1 型糖尿病（T1DM）的一种危及生命的并发症，在 COVID-19 大流行期间有所增加。我们的研究纳入了 25 篇论文，共纳入了 124597 名糖尿病儿童。与之前相比，大流行期间新发 T1DM 患者发生 DKA 的风险呈统计学显著增加。我们的研究结果表明，COVID-19 可能改变了 T1DM 的临床表现，并且可能与 DKA 的严重程度有关。
