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《前列腺癌患者心血管风险与并发症管理台湾共识》

Taiwan Consensus for the Management of Cardiovascular Risks and Complications in Patients with Prostate Cancer.

作者信息

Chang Wei-Ting, Hong Jiang-Huang, Chen Dong-Yi, Huang Chao-Yuan, Chen Yen-Chou, Cha Tai-Lung, Wu Yen-Wen, Lin Tzu-Ping, Cheng Kai-Hung, Chiang Pei-Jhang, Hung Chung-Lieh, Wang Shian-Shiang, Wang Wen-Hwa, Shao I-Hung, Liao Jo-Nan, Hung Sheng-Chun, Lin Hung-Ju, Huang Shu-Pin, Liu Ping-Yen, Huang Kuan-Hua, Wang Tzung-Dau, Lin Jen-Tai, Li Yi-Heng, Wu Hsi-Chin, Pang Jacob See-Tong, Chen Wen-Jone

机构信息

Department of Cardiology, Chi Mei Medical Center, Tainan; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung.

Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei.

出版信息

Acta Cardiol Sin. 2025 May;41(3):288-310. doi: 10.6515/ACS.202505_41(3).20250224A.

Abstract

Prostate cancer (PC) is one of the leading causes of cancer-related deaths among men globally, and it frequently coexists with cardiovascular disease (CVD). With increasing cancer survival rates and an aging population, the incidence of CVD among PC patients is also on the rise. The treatments for PC include androgen deprivation therapy, androgen receptor pathway inhibitors, and docetaxel-based chemotherapy, and the cardiovascular complications include hypertension, metabolic syndrome, heart failure and arrhythmias. As it is important to provide personalized treatment planning and close monitoring, cardio-oncology collaboration plays a crucial role in optimizing treatment outcomes, emphasizing cardiovascular risk assessments and tailored treatment plans that balance cancer control and cardiovascular health. In this consensus statement, we review several important issues including the association between CVD and PC, screening for cardiovascular diseases and risk factors, timing and criteria for cardiology referral, cardiovascular risk assessments and management, and multidisciplinary collaboration and patient education. However, challenges remain in screening and preventive measures, and future research should focus on developing robust cardiovascular risk assessment tools, preventive measures, and interdisciplinary approaches to improve patient outcomes and reduce cardiovascular morbidity in patients being treated for PC.

摘要

前列腺癌(PC)是全球男性癌症相关死亡的主要原因之一,且常与心血管疾病(CVD)共存。随着癌症生存率的提高和人口老龄化,PC患者中CVD的发病率也在上升。PC的治疗方法包括雄激素剥夺疗法、雄激素受体途径抑制剂和基于多西他赛的化疗,其心血管并发症包括高血压、代谢综合征、心力衰竭和心律失常。由于提供个性化治疗方案和密切监测很重要,心脏肿瘤协作在优化治疗结果方面起着关键作用,强调心血管风险评估和平衡癌症控制与心血管健康的定制治疗方案。在本共识声明中,我们回顾了几个重要问题,包括CVD与PC之间的关联、心血管疾病和危险因素的筛查、心脏科转诊的时机和标准、心血管风险评估与管理以及多学科协作和患者教育。然而,筛查和预防措施仍存在挑战,未来的研究应侧重于开发强大的心血管风险评估工具、预防措施和跨学科方法,以改善患者预后并降低PC治疗患者的心血管发病率。

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