Wang Rui, Li Wangshu, Yang Jinliang, Aziz Aziz Ur Rehman, Ha Chunfang
General Hospital of Ningxia Medical University, Yinchuan, China.
Key Laboratory for Early Diagnosis and Biotherapy of Malignant Tumors in Children and Women, Dalian Women and Children's Medical Group, Dalian, Liaoning, China.
Front Public Health. 2025 May 9;13:1555946. doi: 10.3389/fpubh.2025.1555946. eCollection 2025.
Pelvic organ prolapse (POP) is a prevalent condition affecting millions of women globally. Understanding its temporal trends and regional disparities is essential for effective public health interventions.
A cross-sectional analysis was conducted using data from the Global Burden of Disease (GBD) study, examining trends in POP incidence, mortality, and disability-adjusted life years (DALYs) from 1990 to 2021. We analyzed the estimated annual percentage change (EAPC) and explored the association with the socio-demographic index (SDI).
From 1990 to 2021, global POP cases increased from approximately 8.4 million to 14.0 million, while the age-standardized incidence rate (ASIR) declined from 374.84 to 317.51 per 100,000 population (EAPC = -0.46). Deaths rose from 281 to 486, but the age-standardized death rate (ASDR) remained stable. DALYs increased from 232,432 to 389,358, with a decrease in age-standardized DALY rate (EAPC = -0.59). Low-SDI regions exhibited the highest ASIR, ASDR, and DALYs in 2021.
The global burden of pelvic organ prolapse has increased in absolute numbers, although age-standardized rates have declined. Low-SDI regions continue to face the highest burden, highlighting the need for targeted healthcare interventions.
盆腔器官脱垂（POP）是一种普遍存在的疾病，全球数百万女性受其影响。了解其时间趋势和地区差异对于有效的公共卫生干预至关重要。
利用全球疾病负担（GBD）研究的数据进行横断面分析，研究1990年至2021年期间POP的发病率、死亡率和伤残调整生命年（DALY）的趋势。我们分析了估计的年百分比变化（EAPC），并探讨了与社会人口指数（SDI）的关联。
从1990年到2021年，全球POP病例从约840万增加到1400万，而年龄标准化发病率（ASIR）从每10万人374.84例下降到317.51例（EAPC = -0.46）。死亡人数从281人上升到486人，但年龄标准化死亡率（ASDR）保持稳定。DALY从232,432增加到389,358，年龄标准化DALY率下降（EAPC = -0.59）。2021年，低SDI地区的ASIR、ASDR和DALY最高。
尽管年龄标准化率有所下降，但盆腔器官脱垂的全球负担在绝对数量上有所增加。低SDI地区继续面临最高负担，这突出了有针对性的医疗保健干预措施的必要性。
